Neuropil Threads

Abnormal structures located chiefly in distal dendrites and, along with NEUROFIBRILLARY TANGLES and SENILE PLAQUES, constitute the three morphological hallmarks of ALZHEIMER DISEASE. Neuropil threads are made up of straight and paired helical filaments which consist of abnormally phosphorylated microtubule-associated tau proteins. It has been suggested that the threads have a major role in the cognitive impairment seen in Alzheimer disease.

Year introduced: 1998

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Tree Number(s): A08.637.500.550, A08.675.703.550, A11.284.430.214.190.750.602.620, A11.650.500.550, A11.671.685.550

MeSH Unique ID: D019600

Entry Terms:

• Neuropil Thread

All MeSH Categories
Anatomy Category
Nervous System
Neuroglia
Neuropil
Neuropil Threads

All MeSH Categories
Anatomy Category
Nervous System
Neurons
Neuropil
Neuropil Threads

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Anatomy Category
Cells
Cellular Structures
Intracellular Space
Cytoplasm
Cytoplasmic Structures
Cytoskeleton
Microtubules
Neuropil Threads

All MeSH Categories
Anatomy Category
Cells
Neuroglia
Neuropil
Neuropil Threads

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Anatomy Category
Cells
Neurons
Neuropil
Neuropil Threads