Calcineurin

A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.

Year introduced: 1998

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Tree Number(s): D08.811.277.352.650.625.150, D12.644.360.087, D12.776.476.559.150

MeSH Unique ID: D019703

Registry Number: EC 3.1.3.16

Entry Terms:

• Protein Phosphatase-2B
• Protein Phosphatase 2B
• Protein Phosphatase 3
• Phosphatase 3, Protein
• Calcineurin B
• Protein Phosphatase 3 Regulatory Subunit
• Calcineurin A
• Protein Phosphatase 3 Catalytic Subunit

Previous Indexing:

• Calcium-Binding Proteins (1986-1997)
• Calmodulin-Binding Proteins (1986-1997)
• Phosphoprotein Phosphatase (1988-1997)

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Hydrolases
Esterases
Phosphoric Monoester Hydrolases
Phosphoprotein Phosphatases
Calcineurin

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Peptides
Intracellular Signaling Peptides and Proteins
Calcineurin

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Intracellular Signaling Peptides and Proteins
Phosphoprotein Phosphatases
Calcineurin