Immunophilins
Members of a family of highly conserved proteins which are all cis-trans peptidyl-prolyl isomerases (PEPTIDYLPROLYL ISOMERASE). They bind the immunosuppressant drugs CYCLOSPORINE; TACROLIMUS and SIROLIMUS. They possess rotamase activity, which is inhibited by the immunosuppressant drugs that bind to them.
Year introduced: 2004(1999)
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Subheadings:
Tree Number(s): D08.811.399.325.500.400, D12.776.543.750.705.400, D12.776.827.344
MeSH Unique ID: D020104
Registry Number: EC 5.2.1.8
Entry Terms:
- Immunophilin
- Neurophilins
- Neurophilin
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