Myasthenia Gravis, Autoimmune, Experimental
Any autoimmune animal disease model used in the study of MYASTHENIA GRAVIS. Injection with purified neuromuscular junction acetylcholine receptor (AChR) (see RECEPTORS, CHOLINERGIC) components results in a myasthenic syndrome that has acute and chronic phases. The motor endplate pathology, loss of acetylcholine receptors, presence of circulating anti-AChR antibodies, and electrophysiologic changes make this condition virtually identical to human myasthenia gravis. Passive transfer of AChR antibodies or lymphocytes from afflicted animals to normals induces passive transfer experimental autoimmune myasthenia gravis. (From Joynt, Clinical Neurology, 1997, Ch 54, p3)
Year introduced: 2005 (2000)
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Tree Number(s): C10.114.656.300, C10.114.703.350, C10.668.758.725.300, C20.111.258.500.300, C20.111.258.625.350, E05.598.500.500.750
MeSH Unique ID: D020720
Entry Terms:
- Myasthenia Gravis, Experimental Autoimmune
- Myasthenia Gravis, Autoimmune Experimental
- Autoimmune Experimental Myasthenia Gravis
- Experimental Myasthenia
- Experimental Myasthenias
- Myasthenia, Experimental
- Myasthenias, Experimental
- Experimental Myasthenia Gravis
- Myasthenia Gravis, Experimental
- Experimental Autoimmune Myasthenia Gravis, Passive Transfer
- Passive Transfer Experimental Autoimmune Myasthenia Gravis
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