Selective Estrogen Receptor Modulators

A structurally diverse group of compounds distinguished from ESTROGENS by their ability to bind and activate ESTROGEN RECEPTORS but act as either an agonist or antagonist depending on the tissue type and hormonal milieu. They are classified as either first generation because they demonstrate estrogen agonist properties in the ENDOMETRIUM or second generation based on their patterns of tissue specificity. (Horm Res 1997;48:155-63)

Year introduced: 2000

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Tree Number(s): D06.347.360.827, D27.505.696.399.450.360.827

MeSH Unique ID: D020845

Entry Terms:

• SERM
• SERMs
• Estrogen Receptor Modulator, Selective
• Estrogen Receptor Modulators, Selective
• Selective Estrogen Receptor Modulator

Previous Indexing:

• Receptors, Estrogen (1996-1999)

See Also:

• Bone Density Conservation Agents

All MeSH Categories
Chemicals and Drugs Category
Hormones, Hormone Substitutes, and Hormone Antagonists
Hormone Antagonists
Estrogen Receptor Modulators
Selective Estrogen Receptor Modulators

All MeSH Categories
Chemicals and Drugs Category
Chemical Actions and Uses
Pharmacologic Actions
Physiological Effects of Drugs
Hormones, Hormone Substitutes, and Hormone Antagonists
Hormone Antagonists
Estrogen Receptor Modulators
Selective Estrogen Receptor Modulators