Spectrometry, Mass, Electrospray Ionization

A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.

Year introduced: 2001

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Tree Number(s): E05.196.566.600

MeSH Unique ID: D021241

Entry Terms:

• Electrospray Ionization Mass Spectrometry
• ESI Mass Spectrometry
• Mass Spectrometry, ESI
• Spectrometry, ESI Mass

Previous Indexing:

• Spectrum Analysis, Mass (1985-2000)

All MeSH Categories
Analytical, Diagnostic and Therapeutic Techniques and Equipment Category
Investigative Techniques
Chemistry Techniques, Analytical
Mass Spectrometry
Spectrometry, Mass, Electrospray Ionization