RNA-Induced Silencing Complex
A multicomponent, ribonucleoprotein complex comprised of one of the family of ARGONAUTE PROTEINS and the guide strand of the one of the 20- to 30-nucleotide small RNAs. RISC cleaves specific RNAs, which are targeted for degradation by homology to these small RNAs. Functions in regulating gene expression are determined by the specific argonaute protein and small RNA including siRNA (RNA, SMALL INTERFERING), miRNA (MICRORNA), or piRNA (PIWI-INTERACTING RNA).
Year introduced: 2003
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Tree Number(s): D08.811.277.352.355.350.810, D08.811.277.352.700.350.810, D12.776.157.725.500.906, D12.776.664.962.500.906
MeSH Unique ID: D034743
Entry Terms:
- Complex, RNA-Induced Silencing
- RNA Induced Silencing Complex
- Silencing Complex, RNA-Induced
- RISC Multicomponent Nuclease
- Multicomponent Nuclease, RISC
- Nuclease, RISC Multicomponent
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