Integrin alpha Chains
The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4.
Year introduced: 2003
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Subheadings:
Tree Number(s): D12.776.543.750.705.408.100
MeSH Unique ID: D039001
Entry Terms:
- alpha Chains, Integrin
- Integrin alpha Subunits
- alpha Integrins
- Integrins, alpha
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