Neuropilin-2

Transmembrane receptor for CLASS 3 SEMAPHORINS and several vascular endothelial growth factor isoforms. Neuropilin-2 functions either as a homodimer or as a heterodimer with NEUROPILIN-1. The binding affinity of neuropilin-2 varies for different class 3 semaphorin isoforms and is dependent on the composition of the dimer. The protein also forms receptor complexes with plexins and with VEGF RECEPTORS, which alters the binding characteristics of the receptor.

Year introduced: 2003

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Tree Number(s): D12.776.543.750.590.750

MeSH Unique ID: D039943

Entry Terms:

• Neuropilin 2
• Npn-2 Protein
• Npn 2 Protein
• NRP2 Protein

Previous Indexing:

• Nerve Tissue Proteins (1998-2002)

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Membrane Proteins
Receptors, Cell Surface
Neuropilins
Neuropilin-2