Chromosome Fragile Sites

Specific loci that show up during KARYOTYPING as a gap (an uncondensed stretch in closer views) on a CHROMATID arm after culturing cells under specific conditions. These sites are associated with an increase in CHROMOSOME FRAGILITY. They are classified as common or rare, and by the specific culture conditions under which they develop. Fragile site loci are named by the letters FRA followed by a designation for the specific chromosome, and a letter which refers to which fragile site of that chromosome (e.g. FRAXA refers to fragile site A on the X chromosome. It is a rare, folic acid-sensitive fragile site associated with FRAGILE X SYNDROME.)

Year introduced: 2004

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Tree Number(s): G05.360.340.024.189.610

MeSH Unique ID: D043283

Entry Terms:

• Chromosome Fragile Site
• Fragile Site, Chromosome
• Site, Chromosome Fragile
• Sites, Chromosome Fragile
• Fragile Sites, Chromosome

Previous Indexing:

• Chromosome Fragility (1982-2003)

See Also:

• Chromosome Fragility
• Fragile X Syndrome
• DNA Repeat Expansion

All MeSH Categories
Phenomena and Processes Category
Genetic Phenomena
Genetic Structures
Genome
Genome Components
DNA Sequence, Unstable
Chromosome Fragile Sites