Apoptosis Inducing Factor
A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation.
Year introduced: 2006(1999)
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Subheadings:
Tree Number(s): D08.811.682.608.047, D12.644.360.075.311, D12.776.157.687.063, D12.776.331.161, D12.776.476.075.311, D12.776.660.720.063
MeSH Unique ID: D051033
Entry Terms:
- AIF Apoptosis Regulatory Protein
- Apoptosis-Inducing Factor
- Mitochondrial Apoptosis-Inducing Factor
- Apoptosis-Inducing Factor, Mitochondrial
- Mitochondrial Apoptosis Inducing Factor