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GRB2 Adaptor Protein

A signal transducing adaptor protein that links extracellular signals to the MAP KINASE SIGNALING SYSTEM. Grb2 associates with activated EPIDERMAL GROWTH FACTOR RECEPTOR and PLATELET-DERIVED GROWTH FACTOR RECEPTORS via its SH2 DOMAIN. It also binds to and translocates the SON OF SEVENLESS PROTEINS through its SH3 DOMAINS to activate PROTO-ONCOGENE PROTEIN P21(RAS).

Year introduced: 2006(1992)

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Subheadings:

Tree Number(s): D12.644.360.024.290, D12.776.157.057.041, D12.776.476.024.377

MeSH Unique ID: D051380

Entry Terms:

  • Abundant Src Homology Protein
  • Growth Factor Receptor-Bound Protein-2
  • Growth Factor Receptor Bound Protein 2
  • GRB2 Adaptor Protein, Grb3-3 Isoform
  • GRB2 Adaptor Protein, Grb3 3 Isoform
  • Grb3-3 Adaptor Protein

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