Proto-Oncogene Proteins c-bcr
A serine-threonine kinase that contains a C2 DOMAIN and PLECKSTRIN HOMOLOGY DOMAIN. It also has activity as a GTPASE-ACTIVATING PROTEIN for RAC1 PROTEIN and CDC42 PROTEIN. It functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION and is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients.
Year introduced: 2006(1988)
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Tree Number(s): D08.811.913.696.620.682.700.759, D12.644.360.325.300.099.500, D12.776.476.325.300.099.500, D12.776.476.563.759, D12.776.624.664.700.171
MeSH Unique ID: D051562
Registry Number: EC 2.7.11.1
Entry Terms:
- c-bcr, Proto-Oncogene Proteins
- Proto Oncogene Proteins c bcr
- Proto-Oncogene Protein c-bcr
- c-bcr, Proto-Oncogene Protein
- Proto Oncogene Protein c bcr
- Breakpoint Cluster Region Protein
- Proto-Oncogene Protein bcr
- Proto Oncogene Protein bcr
- c-bcr Proto-Oncogene Proteins
- c bcr Proto Oncogene Proteins
- Proto-Oncogene Proteins, c-bcr
- bcr Proto-Oncogene Proteins
- bcr Proto Oncogene Proteins
- Proto-Oncogene Proteins, bcr
- c-bcr Proteins
- c bcr Proteins