Protein Kinase C-alpha

A cytoplasmic serine threonine kinase involved in regulating CELL DIFFERENTIATION and CELLULAR PROLIFERATION. Overexpression of this enzyme has been shown to promote PHOSPHORYLATION of BCL-2 PROTO-ONCOGENE PROTEINS and chemoresistance in human acute leukemia cells.

Year introduced: 2006(1999)

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Tree Number(s): D08.811.913.696.620.682.700.725.100, D12.776.476.563.725.100

MeSH Unique ID: D051571

Registry Number: EC 2.7.11.13

Entry Terms:

• Protein Kinase C(alpha)
• Protein Kinase C alpha
• PKC-alpha Serine-Threonine Kinase
• PKC alpha Serine Threonine Kinase
• Serine-Threonine Kinase, PKC-alpha

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Transferases
Phosphotransferases
Phosphotransferases (Alcohol Group Acceptor)
Protein Kinases
Protein Serine-Threonine Kinases
Protein Kinase C
Protein Kinase C-alpha

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Intracellular Signaling Peptides and Proteins
Protein Serine-Threonine Kinases
Protein Kinase C
Protein Kinase C-alpha