B7-2 Antigen
A costimulatory ligand glycoprotein that contains a C2 and V-type IMMUNOGLOBULIN DOMAIN. It is expressed by ANTIGEN-PRESENTING CELLS and binds to CD28 ANTIGEN with high specificity and to CTLA-4 ANTIGEN with low specificity. The interaction of CD86 with CD28 ANTIGEN provides a stimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Year introduced: 2018 (1993)
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Subheadings:
Tree Number(s): D12.776.465.500, D12.776.467.150.200, D12.776.543.095.200, D23.050.301.285.200, D23.529.168.200
MeSH Unique ID: D051940
Entry Terms:
- B7 2 Antigen
- Early T Cell Costimulatory Molecule 1
- Antigens, CD86
- CD86 Antigens
- Antigen, B7-2
- Antigen, B7 2
- B7-2 Costimulatory Molecule
- Costimulatory Molecule, B7-2
- CD86 Antigen
- Antigen, CD86
- B70 Costimulatory Molecule
- Costimulatory Molecule, B70
See Also: