Janus Kinase 2

A Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPTORS; and a variety of CYTOKINE RECEPTORS such as ERYTHROPOIETIN RECEPTORS and INTERLEUKIN RECEPTORS. Dysregulation of Janus kinase 2 due to GENETIC TRANSLOCATIONS have been associated with a variety of MYELOPROLIFERATIVE DISORDERS.

Year introduced: 2007(1992)

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Tree Number(s): D08.811.913.696.620.682.725.124.200, D12.776.476.568.124.200, D12.776.624.664.700.117

MeSH Unique ID: D053614

Registry Number: EC 2.7.10.2

Entry Terms:

• JAK2 Protein Tyrosine Kinase
• JAK-2 Protein Tyrosine Kinase
• JAK 2 Protein Tyrosine Kinase

See Also:

• src Homology Domains

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Transferases
Phosphotransferases
Phosphotransferases (Alcohol Group Acceptor)
Protein Kinases
Protein-Tyrosine Kinases
Janus Kinases
Janus Kinase 2

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Intracellular Signaling Peptides and Proteins
Protein-Tyrosine Kinases
Janus Kinases
Janus Kinase 2

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Neoplasm Proteins
Oncogene Proteins
Proto-Oncogene Proteins
Janus Kinase 2