Presenilin-2

Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN2 mutations cause ALZHEIMER DISEASE type 4.

Year introduced: 2007

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Tree Number(s): D12.776.543.696.750

MeSH Unique ID: D053766

Entry Terms:

• Presenilin 2

Previous Indexing:

• Alzheimer Disease (1996-2006)
• Membrane Proteins (1996-2006)

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Membrane Proteins
Presenilins
Presenilin-2