Perforin

A calcium-dependent pore-forming protein synthesized in cytolytic LYMPHOCYTES and sequestered in secretory granules. Upon immunological reaction between a cytolytic lymphocyte and a target cell, perforin is released at the plasma membrane and polymerizes into transmembrane tubules (forming pores) which lead to death of a target cell.

Year introduced: 2008

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Tree Number(s): D12.776.543.695.875

MeSH Unique ID: D054353

Registry Number: 126465-35-8

Entry Terms:

• Perforin 1
• Cytolysin
• Lymphocyte Pore-Forming Protein
• Lymphocyte Pore Forming Protein
• Pore-Forming Protein, Lymphocyte

Previous Indexing:

• Membrane Glycoproteins (1985-2007)
• Pore Forming Cytotoxic Proteins (1985-2007)

Pharmacologic Action:

• Cytotoxins

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Membrane Proteins
Pore Forming Cytotoxic Proteins
Perforin