Agouti Signaling Protein

A secreted protein of approximately 131 amino acids (depending on species) that regulates the synthesis of eumelanin (brown/black) pigments in MELANOCYTES. Agouti protein antagonizes the signaling of MELANOCORTIN RECEPTORS and has wide distribution including ADIPOSE TISSUE; GONADS; and HEART. Its overexpression in agouti mice results in uniform yellow coat color, OBESITY, and metabolic defects similar to type II diabetes in humans.

Year introduced: 2008 (1993)

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Tree Number(s): D12.644.276.049, D12.776.467.049, D23.529.049

MeSH Unique ID: D054366

Entry Terms:

• Agouti Protein
• Agouti Switch Protein
• ASIP Protein

Previous Indexing:

• Intercellular Signaling Peptides and Proteins (1994-2007)

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Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Peptides
Intercellular Signaling Peptides and Proteins
Agouti Signaling Protein

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Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Intercellular Signaling Peptides and Proteins
Agouti Signaling Protein

All MeSH Categories
Chemicals and Drugs Category
Biological Factors
Intercellular Signaling Peptides and Proteins
Agouti Signaling Protein