Pre-B Cell Receptors

Membrane proteins in precursor B-LYMPHOCYTES (pre-B Cells). They are composed of membrane-bound MU IMMUNOGLOBULIN HEAVY CHAINS in complex with SURROGATE LIGHT CHAINS instead of conventional IMMUNOGLOBULIN LIGHT CHAINS. Only successful rearrangement of the VDJ segments, at the Ig heavy chain gene locus (IMMUNOGLOBULIN HEAVY CHAIN GENES), will generate mu heavy chains that can pair with surrogate light chains. Thus formation of the pre-B cell receptors is an important checkpoint in the development of mature B cells.

Year introduced: 2008

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Tree Number(s): D12.776.124.790.651.950.750, D12.776.377.715.548.950.750, D12.776.543.750.705.816.821.750

MeSH Unique ID: D054420

Entry Terms:

• Cell Receptors, Pre-B
• Pre B Cell Receptors
• Receptors, Pre-B Cell
• Pre-B Cell Receptor
• Cell Receptor, Pre-B
• Pre B Cell Receptor
• Receptor, Pre-B Cell

Previous Indexing:

• Receptors, Antigen, B-Cell (1995-2007)

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Blood Proteins
Serum Globulins
Immunoglobulins
Receptors, Antigen, B-Cell
Pre-B Cell Receptors
Immunoglobulin Light Chains, Surrogate

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Globulins
Serum Globulins
Immunoglobulins
Receptors, Antigen, B-Cell
Pre-B Cell Receptors
Immunoglobulin Light Chains, Surrogate

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Membrane Proteins
Receptors, Cell Surface
Receptors, Immunologic
Receptors, Antigen
Receptors, Antigen, B-Cell
Pre-B Cell Receptors
Immunoglobulin Light Chains, Surrogate