Protein Tyrosine Phosphatase, Non-Receptor Type 22
A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of an N-terminal catalytic domain and a C-terminal PROLINE-rich domain. The phosphatase subtype is predominantly expressed in LYMPHOCYTES and plays a key role in the inhibition of downstream T-LYMPHOCYTE activation. Polymorphisms in the gene that encodes this phosphatase subtype are associated with a variety of AUTOIMMUNE DISEASES.
Year introduced: 2008(1999)
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Subheadings:
Tree Number(s): D08.811.277.352.650.775.300.930, D12.776.476.564.300.930
MeSH Unique ID: D054596
Registry Number: EC 3.1.3.48
Entry Terms:
- Protein Tyrosine Phosphatase, Non Receptor Type 22
- PTPN-22 Protein
- PTPN 22 Protein
- PTPase Lyp
- Protein-Tyrosine Phosphatase Lyp
- Protein Tyrosine Phosphatase Lyp
- Lymphoid Phosphatase
- Tyrosine Protein Phosphatase, Non-Receptor Type 22
- Tyrosine Protein Phosphatase, Non Receptor Type 22
- Lyp1 PTPase
- PTPase, Lyp1
- Lyp2 PTPase
- PTPase, Lyp2