Insulin Receptor Substrate Proteins
A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share an N-terminal PLECKSTRIN HOMOLOGY DOMAIN, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation, insulin receptor substrate proteins interact with specific SH2 DOMAIN containing proteins that are involved in insulin receptor signaling.
Year introduced: 2009(1992)
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Subheadings:
Tree Number(s): D12.644.360.024.301, D12.776.157.057.045, D12.776.476.024.382
MeSH Unique ID: D055504
Entry Terms:
- IRS Signaling Adaptor Proteins
- Insulin Receptor Substrate-1 Protein
- Insulin Receptor Substrate 1 Protein
- Insulin Receptor Substrate-1
- Insulin Receptor Substrate 1
- Insulin Receptor Substrate-2 Protein
- Insulin Receptor Substrate 2 Protein
- Insulin Receptor Substrate-2
- Insulin Receptor Substrate 2
- Insulin Receptor Substrate-3 Protein
- Insulin Receptor Substrate 3 Protein
- Insulin Receptor Substrate-3
- Insulin Receptor Substrate 3
- Insulin Receptor Substrate-4 Protein
- Insulin Receptor Substrate 4 Protein
- Insulin Receptor Substrate-4
- Insulin Receptor Substrate 4
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