Jumonji Domain-Containing Histone Demethylases

A family of histone demethylases that share a conserved Jumonji C domain. The enzymes function via an iron-dependent dioxygenase mechanism that couples the conversion of 2-oxoglutarate to succinate to the hydroxylation of N-methyl groups.

Year introduced: 2010

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Tree Number(s): D08.811.682.662.582.475.500, D08.811.682.690.416.388

MeSH Unique ID: D056484

Registry Number: EC 1.14.11.-

Entry Terms:

• Jumonji Domain Containing Histone Demethylases
• JmjC Domain-Containing Histone Demethylases
• JmjC Domain Containing Histone Demethylases

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Oxidoreductases
Oxidoreductases Acting on CH-NH Group Donors
Oxidoreductases, N-Demethylating
Histone Demethylases
Jumonji Domain-Containing Histone Demethylases
Retinoblastoma-Binding Protein 2

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Oxidoreductases
Oxygenases
Dioxygenases
Jumonji Domain-Containing Histone Demethylases
Retinoblastoma-Binding Protein 2