Axin Signaling Complex

A specific complex of WNT SIGNALING PATHWAY proteins that mediates the phosphorylation-dependent destruction of cytosolic BETA-CATENIN. The complex is disrupted by cell surface binding of WNT PROTEINS, which allows beta-catenin levels to rise to the point where they migrate to the CELL NUCLEUS and activate transcription.

Year introduced: 2012

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Do not include MeSH terms found below this term in the MeSH hierarchy.

Tree Number(s): D05.500.117, D12.776.476.081

MeSH Unique ID: D060465

Entry Terms:

• Signaling Complex, Axin
• Axin Signaling Complex Proteins
• beta-Catenin Destruction Complex
• beta Catenin Destruction Complex
• Destruction Complex, beta-Catenin

All MeSH Categories
Chemicals and Drugs Category
Macromolecular Substances
Multiprotein Complexes
Axin Signaling Complex
Adenomatous Polyposis Coli Protein
Axin Protein
Casein Kinase I
Casein Kinase 1 epsilon
Casein Kinase Ialpha
Casein Kinase Idelta
Glycogen Synthase Kinase 3
Glycogen Synthase Kinase 3 beta

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Intracellular Signaling Peptides and Proteins
Axin Signaling Complex
Adenomatous Polyposis Coli Protein
Axin Protein
Glycogen Synthase Kinase 3
Glycogen Synthase Kinase 3 beta