Peroxisomal Multifunctional Protein-2
A dimeric protein found in liver peroxisomes that plays an important role in FATTY ACID metabolism and steroid metabolism. The dimer is formed by cleavage of a single protein precursor and contains an enoyl-CoA hydratase-2 domain and a second domain that displays (S)-3-hydroxyacyl-CoA dehydrogenase and 17-beta-estradiol dehydrogenase activities. The enzyme is stereospecific with regards to arrangement of the substrate double bonds and position of the 3-hydroxy group of the reaction intermediate. It is complemented by PEROXISOMAL BIFUNCTIONAL ENZYME, which has the opposite reaction stereospecificity.
Year introduced: 2014
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Subheadings:
Tree Number(s): D08.811.520.241.300.275.500, D08.811.641.812, D08.811.682.047.436.375.640, D08.811.682.047.820.150.926
MeSH Unique ID: D064029
Registry Number: EC 4.2.1.107
Entry Terms:
- Multifunctional Protein-2, Peroxisomal
- Peroxisomal Multifunctional Protein 2
- 17-beta-Hydroxysteroid Dehydrogenase 4
- 17 beta Hydroxysteroid Dehydrogenase 4
- 4, 17-beta-Hydroxysteroid Dehydrogenase
- Dehydrogenase 4, 17-beta-Hydroxysteroid
- 3-alpha,7-alpha,12-alpha-Trihydroxy-5-beta-Cholest-24-enoyl-CoA Hydratase
- Peroxisomal Multifunctional Enzyme Type 2
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