Subacute Sclerosing Panencephalitis
A rare, slowly progressive encephalitis caused by chronic infection with the MEASLES VIRUS. The condition occurs primarily in children and young adults, approximately 2-8 years after the initial infection. A gradual decline in intellectual abilities and behavioral alterations are followed by progressive MYOCLONUS; MUSCLE SPASTICITY; SEIZURES; DEMENTIA; autonomic dysfunction; and ATAXIA. DEATH usually occurs 1-3 years after disease onset. Pathologic features include perivascular cuffing, eosinophilic cytoplasmic inclusions, neurophagia, and fibrous gliosis. It is caused by the SSPE virus, which is a defective variant of MEASLES VIRUS. (From Adams et al., Principles of Neurology, 6th ed, pp767-8)
Year introduced: 1971
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Tree Number(s): C01.207.245.340.600, C01.207.399.750.600, C01.925.182.525.600, C01.925.782.580.600.500.500.800, C01.925.839.862, C10.228.140.430.520.750.600, C10.228.228.245.340.600, C10.228.228.399.750.600, C10.586.250.520.750.600
MeSH Unique ID: D013344
Entry Terms:
- Panencephalitides, Subacute Sclerosing
- Sclerosing Panencephalitides, Subacute
- Subacute Sclerosing Panencephalitides
- SSPE
- Sclerosing Panencephalitis, Subacute
- Panencephalitis, Subacute Sclerosing
- Inclusion Body Encephalitis, Measles
- Van Bogaert's Leukoencephalitis
- Van Bogaert Leukoencephalitis
- Van Bogaerts Leukoencephalitis
- Sclerosing Leukoencephalitis, Subacute
- Leukoencephalitides, Subacute Sclerosing
- Sclerosing Leukoencephalitides, Subacute
- Subacute Sclerosing Leukoencephalitides
- Subacute Sclerosing Leukoencephalitis
- Leukoencephalitis, Subacute Sclerosing
- Measles Inclusion Body Encephalitis
- Encephalitis, Inclusion Body, Measles
- Leukoencephalitis, Van Bogaert's
- Leukoencephalitis, Van Bogaert
- Leukoencephalitis, Van Bogaerts
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