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Leukodystrophy, Metachromatic

An autosomal recessive metabolic disease caused by a deficiency of CEREBROSIDE-SULFATASE leading to intralysosomal accumulation of cerebroside sulfate (SULFOGLYCOSPHINGOLIPIDS) in the nervous system and other organs. Pathological features include diffuse demyelination, and metachromatically-staining granules in many cell types such as the GLIAL CELLS. There are several allelic and nonallelic forms with a variety of neurological symptoms.

Year introduced: 1974

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Tree Number(s): C10., C10., C10.228.140.695.625.550, C10.314.400.550, C16.320.565.189.362.550, C16.320.565.189.435.825.850.500, C16.320.565.398.641.803.925.500, C16.320.565.595.554.825.850.500, C18.452.132.100.362.550, C18.452.132.100.435.825.850.500, C18.452.584.563.641.803.925.500, C18.452.648.189.362.550, C18.452.648.189.435.825.850.500, C18.452.648.398.641.803.925.500, C18.452.648.595.554.825.850.500

MeSH Unique ID: D007966

Entry Terms:

  • Leukodystrophies, Metachromatic
  • Metachromatic Leukodystrophies
  • Arylsulfatase A Deficiency Disease
  • Cerebroside Sulphatase Deficiency Disease
  • Sulfatide Lipidosis
  • Lipidosis, Sulfatide
  • Metachromatic Leukoencephalopathy
  • Leukoencephalopathies, Metachromatic
  • Leukoencephalopathy, Metachromatic
  • Metachromatic Leukoencephalopathies
  • Cerebral sclerosis, Diffuse, Metachromatic Form
  • Metachromatic Leukodystrophy
  • Leukodystrophy, Metachromatic, Adult
  • Metachromatic Leukodystrophy, Adult-Type
  • Adult-Type Metachromatic Leukodystrophies
  • Adult-Type Metachromatic Leukodystrophy
  • Leukodystrophies, Adult-Type Metachromatic
  • Leukodystrophy, Adult-Type Metachromatic
  • Metachromatic Leukodystrophies, Adult-Type
  • Metachromatic Leukodystrophy, Adult Type
  • Metachromatic Leukodystrophy, Adult
  • Adult Metachromatic Leukodystrophies
  • Adult Metachromatic Leukodystrophy
  • Leukodystrophies, Adult Metachromatic
  • Leukodystrophy, Adult Metachromatic
  • Metachromatic Leukodystrophies, Adult
  • Leukodystrophy, Metachromatic, Juvenile
  • Metachromatic Leukodystrophy, Juvenile-Type
  • Juvenile-Type Metachromatic Leukodystrophies
  • Juvenile-Type Metachromatic Leukodystrophy
  • Leukodystrophies, Juvenile-Type Metachromatic
  • Leukodystrophy, Juvenile-Type Metachromatic
  • Metachromatic Leukodystrophies, Juvenile-Type
  • Metachromatic Leukodystrophy, Juvenile Type
  • Metachromatic Leukodystrophy, Juvenile
  • Juvenile Metachromatic Leukodystrophies
  • Juvenile Metachromatic Leukodystrophy
  • Leukodystrophies, Juvenile Metachromatic
  • Leukodystrophy, Juvenile Metachromatic
  • Metachromatic Leukodystrophies, Juvenile
  • Metachromatic Leukodystrophy, Infant
  • Infant Metachromatic Leukodystrophies
  • Infant Metachromatic Leukodystrophy
  • Metachromatic Leukodystrophies, Infant
  • Greenfield Disease
  • Greenfield's Disease
  • Metachromatic Leukodystrophy, Infant-Type
  • Infant-Type Metachromatic Leukodystrophies
  • Infant-Type Metachromatic Leukodystrophy
  • Metachromatic Leukodystrophies, Infant-Type
  • Metachromatic Leukodystrophy, Infant Type
  • Metachromatic Leukodystrophy, Late Infantile
  • Arylsulfatase A Deficiency
  • Arylsulfatase A Deficiencies
  • Deficiencies, Arylsulfatase A
  • Deficiency, Arylsulfatase A
  • Cerebroside Sulfatase Deficiency
  • Cerebroside Sulfatase Deficiencies
  • Deficiencies, Cerebroside Sulfatase
  • Deficiency, Cerebroside Sulfatase
  • Sulfatase Deficiencies, Cerebroside
  • Sulfatase Deficiency, Cerebroside
  • ARSA Deficiency
  • ARSA Deficiencies
  • Deficiencies, ARSA
  • Deficiency, ARSA

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