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Deafness, Autosomal Recessive 4 [Supplementary Concept]

A hereditary autosomal recessive disorder characterized by the onset of SENSORINEURAL HEARING LOSS or MIXED HEARING LOSS typically in infancy. It is associated with TEMPORAL BONE abnormalities, especially an enlarged vestibular aqueduct, but it can also include the more severe Mondini dysplasia, a complex malformation in which the normal cochlear spiral of 2.5 turns is replaced by a hypoplastic coil of 1.5 turns. Mutations have been identified in the SLC26A4 gene, and more rarely the FOXI1 gene for enlarged vestibular aqueduct. OMIM: 600791

Date introduced: November 5, 2012

MeSH Unique ID: C566366

Heading Mapped to:

Entry Terms:

  • Dilated Vestibular Aqueduct
  • Neurosensory Nonsyndromic Recessive Deafness 4
  • Enlarged Vestibular Aqueduct

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