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Choroid Plexus Carcinoma [Supplementary Concept]

Malignant neoplasms originating from the CHOROID PLEXUS.They are neuroectodermal in origin and can range from benign choroid plexus papillomas (CPPs) to malignant choroid carcinomas (CPCs). These rare tumors generally occur in childhood, but have also been reported in adults. Patients typically present with signs and symptoms of increased intracranial pressure including headache, HYDROCEPHALUS; PAPILLEDEMA, nausea, vomiting, cranial nerve deficits, gait impairment, and seizures. Tumor cells show anaplastic features and often invade neighboring brain structures. Cerebrospinal fluid metastases are common. Germline mutations in the TP53 gene have been identified. OMIM: 260500

Date introduced: November 5, 2012

MeSH Unique ID: C562943

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