MeSH

A semisynthetic analog of PACLITAXEL used in the treatment of locally advanced or metastatic BREAST NEOPLASMS and NON-SMALL CELL LUNG CANCER.

Year introduced: 2019 (1991)

Agents that interact with TUBULIN to inhibit or promote polymerization of MICROTUBULES.

Year introduced: 2006

Substances that inhibit or prevent the proliferation of NEOPLASMS.

A group of diterpenoid CYCLODECANES named for the taxanes that were discovered in the TAXUS tree. The action on MICROTUBULES has made some of them useful as ANTINEOPLASTIC AGENTS.

Year introduced: 2004

Compounds with a 10-carbon ring.

Year introduced: 2004

A class of compounds composed of repeating 5-carbon units of HEMITERPENES.

A broad class of substances containing carbon and its derivatives. Many of these chemicals will frequently contain hydrogen with or without oxygen, nitrogen, sulfur, phosphorus, and other elements. They exist in either carbon chain or carbon ring form.

Year introduced: 1998

Organic compounds composed exclusively of carbon and hydrogen forming a closed ring that may be either alicyclic or aromatic.

Year introduced: 1998

Organic compounds composed exclusively of carbon and hydrogen. Three or more carbon atoms are arranged in a cyclic structure and they possess aliphatic properties.

Year introduced: 1998

Organic compounds that primarily contain carbon and hydrogen atoms with the carbon atoms forming a linear or circular structure.

Twenty-carbon compounds derived from MEVALONIC ACID or deoxyxylulose phosphate.

Year introduced: 1974

Alicyclic hydrocarbons in which three or more of the carbon atoms in each molecule are united in a ring structure and each of the ring carbon atoms is joined to two hydrogen atoms or alkyl groups. The simplest members are cyclopropane (C3H6), cyclobutane (C4H8), cyclohexane (C6H12), and derivatives of these such as methylcyclohexane (C6H11CH3). (From Sax, et al., Hawley's Condensed Chemical Dictionary, 11th ed)

Agents that affect MITOSIS of CELLS.

Year introduced: 2006

Agents that arrest cells in MITOSIS, most notably TUBULIN MODULATORS.

Year introduced: 2006

Uses of chemicals which affect the course of conditions, diseases, syndromes or pathology to benefit the health of an individual.

Year introduced: 2004

Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY.

Year introduced: 2008(2004)

A broad category of chemical actions and uses that result in the prevention, treatment, cure or diagnosis of disease. Included here are drugs and chemicals that act by altering normal body functions, such as the REPRODUCTIVE CONTROL AGENTS and ANESTHETICS. Effects of chemicals on the environment are also included.

Year introduced: 2004(1999)

A group of pharmacologic activities, effects on living systems and the environment, and modes of employment of drugs and chemicals. They are broken into actions, which describe their effects, and uses, which describe how they are employed.

Year introduced: 1999