Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
lorlatinib [Supplementary Concept]
inhibits both anaplastic lymphoma kinase and c-ros oncogene 1 (ROS1) protein
Date introduced: August 17, 2014
Pyridines
Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.
Pyrazoles
Azoles of two nitrogens at the 1,2 positions, next to each other, in contrast with IMIDAZOLES in which they are at the 1,3 positions.
Organic Chemicals
A broad class of substances containing carbon and its derivatives. Many of these chemicals will frequently contain hydrogen with or without oxygen, nitrogen, sulfur, phosphorus, and other elements. They exist in either carbon chain or carbon ring form.
Year introduced: 1998
Lactams
Cyclic AMIDES formed from aminocarboxylic acids by the elimination of water. Lactims are the enol forms of lactams.
Year introduced: 1974(1972)
Heterocyclic Compounds, 1-Ring
Organic compounds that contain a ring structure made up of carbon and one or more additional elements such as nitrogen and oxygen.
Heterocyclic Compounds
Cyclic compounds that include atoms other than carbon in their ring structure.
Azoles
Five membered rings containing a NITROGEN atom.
Aminopyridines
Pyridines substituted in any position with an amino group. May be hydrogenated but must retain at least one double bond.
Year introduced: 1979
Amines
A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant and Hackh's Chemical Dictionary, 5th ed)
Amides
Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant and Hackh's Chemical Dictionary, 5th ed)