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Items: 11

1.

lorlatinib [Supplementary Concept]

inhibits both anaplastic lymphoma kinase and c-ros oncogene 1 (ROS1) protein

Date introduced: August 17, 2014

2.

Pyridines

Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.

3.

Pyrazoles

Azoles of two nitrogens at the 1,2 positions, next to each other, in contrast with IMIDAZOLES in which they are at the 1,3 positions.

4.

Organic Chemicals

A broad class of substances containing carbon and its derivatives. Many of these chemicals will frequently contain hydrogen with or without oxygen, nitrogen, sulfur, phosphorus, and other elements. They exist in either carbon chain or carbon ring form.

Year introduced: 1998

5.

Lactams

Cyclic AMIDES formed from aminocarboxylic acids by the elimination of water. Lactims are the enol forms of lactams.

Year introduced: 1974(1972)

6.

Heterocyclic Compounds, 1-Ring

Organic compounds that contain a ring structure made up of carbon and one or more additional elements such as nitrogen and oxygen.

Year introduced: 1998

7.

Heterocyclic Compounds

Cyclic compounds that include atoms other than carbon in their ring structure.

8.

Azoles

Five membered rings containing a NITROGEN atom.

9.

Aminopyridines

Pyridines substituted in any position with an amino group. May be hydrogenated but must retain at least one double bond.

Year introduced: 1979

10.

Amines

A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant and Hackh's Chemical Dictionary, 5th ed)

11.

Amides

Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant and Hackh's Chemical Dictionary, 5th ed)

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