RSPO4 is a potential risk gene of stages III-IV, grade C periodontitis through effects on innate immune response and oral barrier integrity.
Chopra A, Song J, Weiner J 3rd, Keceli HG, Dincer PR, Cruz R, Carracedo A, Blanco J, Dommisch H, Schaefer AS. J Clin Periodontol. 2023 Apr; 50(4):476-486. Epub 2022 Dec 15.