HGNC Approved Gene Symbol: NDRG3
Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:36,651,771-36,746,090 (from NCBI)
In studies of the NDRG gene family in the human, Kalaydjieva et al. (2000) used novel mouse sequences of Ndr2 (see 605272) and Ndr3 to search the human genome databases. This confirmed the existence of a human NDRG3 gene, homologous to mouse Ndr3. Kalaydjieva et al. (2000) stated that the 3 known human NDRG proteins show considerable homology, with 54% amino acid sequence identity between NDRG1 (605262) and NDRG2, 67% between NDRG1 and NDRG3, and 58% between NDRG2 and NDRG3.
Zhou et al. (2001) reported that full-length 375-amino acid NDRG3 protein has a calculated molecular mass of 41.4 kD. Northern blot analysis detected highest expression of a 3.0-kb NDRG3 transcript in brain, followed by heart and kidney. Lower expression was detected in all other tissues examined.
Kalaydjieva et al. (2000) found that the NDRG3 gene was represented by 86 ESTs and a genomic clone from chromosome 20q11.21-q11.23. This provisional chromosomal localization was confirmed by electronic PCR.
Kalaydjieva, L., Gresham, D., Gooding, R., Heather, L., Baas, F., de Jonge, R., Blechschmidt, K., Angelicheva, D., Chandler, D., Worsley, P., Rosenthal, A., King, R. H. M., Thomas, P. K. N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom. Am. J. Hum. Genet. 67: 47-58, 2000. [PubMed: 10831399] [Full Text: https://doi.org/10.1086/302978]
Zhou, R.-H., Kokame, K., Tsukamoto, Y., Yutani, C., Kato, H., Miyata, T. Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart. Genomics 73: 86-97, 2001. [PubMed: 11352569] [Full Text: https://doi.org/10.1006/geno.2000.6496]