Alternative titles; symbols
Cytogenetic location: 5q21 Genomic coordinates (GRCh38): 5:98,900,001-110,200,000
| Location | Phenotype |
Phenotype MIM number |
Inheritance |
Phenotype mapping key |
|---|---|---|---|---|
| 5q21 | {Migraine, susceptibility to, 8} | 609570 | 2 |
In a genomewide linkage study of migraine in Australian twins, Nyholt et al. (2005) found that quantitative-trait linkage analysis produced evidence of significant linkage on 5q21. Evidence of suggestive linkage was obtained on chromosomes 8, 10, and 13. Examination of linkage to individual migraine symptoms (subphenotypes) indicated that individual symptoms were differentially associated with particular linkage peaks in their data. Nyholt et al. (2005) proposed that the chromosome 5 region probably contains a general migrainous headache gene, with all 10 International Headache Society (IHS) symptoms producing a lod score with P less than or equal to 0.05. In a subphenotype analysis for each symptom, in which affected individuals must simply have the individual symptom, regardless of latent-class analysis (LCA) diagnosis, the chromosome 5 locus was most associated with pulsating headache pain (lod = 3.41). The chromosome 8 locus was associated with nausea/vomiting (lod = 1.46) and moderate/severe headache pain (lod = 1.27); the chromosome 10 peak was most associated with phonophobia (lod = 1.44) and photophobia (lod = 1.63); and the chromosome 13 peak was completely due to association with photophobia (lod = 1.55).
Nyholt, D. R., Morley, K. I., Ferreira, M. A. R., Medland, S. E., Boomsma, D. I., Heath, A. C., Merikangas, K. R., Montgomery, G. W., Martin, N. G. Genomewide significant linkage to migrainous headache on chromosome 5q21. Am. J. Hum. Genet. 77: 500-512, 2005. [PubMed: 16080125] [Full Text: https://doi.org/10.1086/444510]