Entry - %609670 - MIGRAINE WITH AURA, SUSCEPTIBILITY TO, 9 - OMIM

 
ICD+
% 609670

MIGRAINE WITH AURA, SUSCEPTIBILITY TO, 9


Alternative titles; symbols

MGR9


Cytogenetic location: 11q24     Genomic coordinates (GRCh38): 11:121,300,001-130,900,000


Gene-Phenotype Relationships
Location Phenotype Phenotype
MIM number 		Inheritance Phenotype
mapping key
11q24 {Migraine with aura, susceptibility to, 9} 609670 2
Phenotypic Series
 

Migraine with or without aura, susceptibility to - PS157300 - 17 Entries
Location Phenotype Inheritance Phenotype
mapping key 		Phenotype
MIM number 		Gene/Locus Gene/Locus
MIM number
1q31 {Migraine, familial hemiplegic, 4} AD 2 607516 MGR6 607516
1q31 {Migraine with or without aura, susceptibility to, 6} AD 2 607516 MGR6 607516
4q24 {Migraine with or without aura, susceptibility to, 1} AD 2 157300 MGR1 157300
4q31.22-q31.23 {Migraine, resistance to} AD 3 157300 EDNRA 131243
5q21 {Migraine, susceptibility to, 8} 2 609570 MGR8 609570
6p21.33 {Migraine without aura, susceptibility to} AD 3 157300 TNF 191160
6p21.1-p12.2 {Migraine with or without aura, susceptibility to, 3} AD 2 607498 MGR3 607498
6q25.1-q25.2 {Migraine, susceptibility to} AD 3 157300 ESR1 133430
10q22-q23 {Migraine, with or without aura, susceptibility to, 12} AD 2 611706 MGR12 611706
10q25.3 {Migraine, with or without aura, susceptibility to, 13} AD 3 613656 KCNK18 613655
11q24 {Migraine with aura, susceptibility to, 9} 2 609670 MGR9 609670
14q21.2-q22.3 {Migraine without aura, susceptibility to, 4} AD 2 607501 MGR4 607501
15q11.2-q12 {Migraine with aura, susceptibility to, 7} 2 609179 MGR7 609179
17p13.1 {Migraine with or without aura, susceptibility to, 10} AD 2 610208 MGR10 610208
18q12.1 {Migraine with or without aura, susceptibility to, 11} AD 2 610209 MGR11 610209
19p13 {Migraine with or without aura, susceptibility to, 5} AD 2 607508 MGR5 607508
Xq {Migraine, familial typical, susceptibility to, 2} XL 2 300125 MGR2 300125
▲ Close

▼ TEXT

For a phenotypic description and discussion of genetic heterogeneity of migraine headaches, see MGR1 (157300).

Cader et al. (2003) undertook a genomewide screen of 43 Canadian families, segregating migraine with aura with families chosen for an apparent autosomal dominant pattern of transmission. Parametric linkage analysis revealed a novel locus on 11q24 with a 2-point lod score of 4.2 at marker GATA64D03 (GenBank G08882) and a multipoint parametric lod score of 5.6 with a peak at the same marker. Several candidate ion channel genes map to this region, including GRIK4 (600282), KCNJ5 (600734), and KCNJ1 (600359).


▼ REFERENCES

  1. Cader, Z. M., Noble-Topham, S., Dyment, D. A., Cherny, S. S., Brown, J. D., Rice, G. P. A., Ebers, G. C. Significant linkage to migraine with aura on chromosome 11q24. Hum. Molec. Genet. 12: 2511-2517, 2003. [PubMed: 12915447, related citations] [Full Text]


Creation Date:
George E. Tiller : 10/20/2005
Edit History:
alopez : 10/20/2005

% 609670

MIGRAINE WITH AURA, SUSCEPTIBILITY TO, 9


Alternative titles; symbols

MGR9


DO: 10024;  


Cytogenetic location: 11q24     Genomic coordinates (GRCh38): 11:121,300,001-130,900,000


Gene-Phenotype Relationships

Location Phenotype Phenotype
MIM number 		Inheritance Phenotype
mapping key
11q24 {Migraine with aura, susceptibility to, 9} 609670 2

TEXT

For a phenotypic description and discussion of genetic heterogeneity of migraine headaches, see MGR1 (157300).

Cader et al. (2003) undertook a genomewide screen of 43 Canadian families, segregating migraine with aura with families chosen for an apparent autosomal dominant pattern of transmission. Parametric linkage analysis revealed a novel locus on 11q24 with a 2-point lod score of 4.2 at marker GATA64D03 (GenBank G08882) and a multipoint parametric lod score of 5.6 with a peak at the same marker. Several candidate ion channel genes map to this region, including GRIK4 (600282), KCNJ5 (600734), and KCNJ1 (600359).


REFERENCES

  1. Cader, Z. M., Noble-Topham, S., Dyment, D. A., Cherny, S. S., Brown, J. D., Rice, G. P. A., Ebers, G. C. Significant linkage to migraine with aura on chromosome 11q24. Hum. Molec. Genet. 12: 2511-2517, 2003. [PubMed: 12915447] [Full Text: https://doi.org/10.1093/hmg/ddg252]


Creation Date:
George E. Tiller : 10/20/2005

Edit History:
alopez : 10/20/2005



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: April 26, 2024