Entry - *611677 - OLFACTORY RECEPTOR, FAMILY 13, SUBFAMILY G, MEMBER 1; OR13G1 - OMIM

 
 
* 611677

OLFACTORY RECEPTOR, FAMILY 13, SUBFAMILY G, MEMBER 1; OR13G1


Alternative titles; symbols

OR1-37


HGNC Approved Gene Symbol: OR13G1

Cytogenetic location: 1q44     Genomic coordinates (GRCh38): 1:247,670,812-247,679,739 (from NCBI)


TEXT

▼ Cloning and Expression

OR1-37 (OR13G1) is a member of a large multigene family encoding transmembrane signaling proteins required for odorant discrimination (Mainic et al., 2004).


▼ Mapping

By sequence analysis, Mainic et al. (2004) mapped the OR1-37 gene to chromosome 1q44.


▼ Molecular Genetics

Family history is a major risk factor for myocardial infarction (MI). Shiffman et al. (2005) hypothesized that a gene-centric association study that was not limited to candidate genes could identify novel genetic associations with MI. They analyzed more than 11,000 SNPs in almost 7,000 genes in 3 sequential studies involving a total of 1,332 Caucasian MI patients and 1,772 controls. They found 4 gene variants associated with MI (p less than 0.05; false-discovery rate less than 10%): palladin (608092) (odds ratio = 1.40); a tyrosine kinase, ROS1 (165020) (OR = 1.75); and 2 G protein-coupled receptors, TAS2R50 (609627) (OR = 1.58), and OR13G1 (OR = 1.40). The odds ratios cited were for carriers of 2 versus 0 risk alleles.


▼ REFERENCES

  1. Mainic, B., Godfrey, P. A., Buck, L. B. The human olfactory receptor gene family. Proc. Nat. Acad. Sci. 101: 2584-2589, 2004. Note: Erratum: 101: 7205 only, 2004. [PubMed: 14983052, related citations] [Full Text]

  2. Shiffman, D., Ellis, S. G., Rowland, C. M., Malloy, M. J., Luke, M. M., Iakoubova, O. A., Pullinger, C. R., Cassano, J., Aouizerat, B. E., Fenwick, R. G., Reitz, R. E., Catanese, J. J., Leong, D. U., Zellner, C., Sninsky, J. J., Topol, E. J., Devlin, J. J., Kane, J. P. Identification of four gene variants associated with myocardial infarction. Am. J. Hum. Genet. 77: 596-605, 2005. [PubMed: 16175505, related citations] [Full Text]


Contributors:
Marla J. F. O'Neill - updated : 12/14/2007
Creation Date:
Patricia A. Hartz : 12/14/2007
Edit History:
carol : 12/14/2007
carol : 12/14/2007

* 611677

OLFACTORY RECEPTOR, FAMILY 13, SUBFAMILY G, MEMBER 1; OR13G1


Alternative titles; symbols

OR1-37


HGNC Approved Gene Symbol: OR13G1

Cytogenetic location: 1q44     Genomic coordinates (GRCh38): 1:247,670,812-247,679,739 (from NCBI)


TEXT

Cloning and Expression

OR1-37 (OR13G1) is a member of a large multigene family encoding transmembrane signaling proteins required for odorant discrimination (Mainic et al., 2004).


Mapping

By sequence analysis, Mainic et al. (2004) mapped the OR1-37 gene to chromosome 1q44.


Molecular Genetics

Family history is a major risk factor for myocardial infarction (MI). Shiffman et al. (2005) hypothesized that a gene-centric association study that was not limited to candidate genes could identify novel genetic associations with MI. They analyzed more than 11,000 SNPs in almost 7,000 genes in 3 sequential studies involving a total of 1,332 Caucasian MI patients and 1,772 controls. They found 4 gene variants associated with MI (p less than 0.05; false-discovery rate less than 10%): palladin (608092) (odds ratio = 1.40); a tyrosine kinase, ROS1 (165020) (OR = 1.75); and 2 G protein-coupled receptors, TAS2R50 (609627) (OR = 1.58), and OR13G1 (OR = 1.40). The odds ratios cited were for carriers of 2 versus 0 risk alleles.


REFERENCES

  1. Mainic, B., Godfrey, P. A., Buck, L. B. The human olfactory receptor gene family. Proc. Nat. Acad. Sci. 101: 2584-2589, 2004. Note: Erratum: 101: 7205 only, 2004. [PubMed: 14983052] [Full Text: https://doi.org/10.1073/pnas.0307882100]

  2. Shiffman, D., Ellis, S. G., Rowland, C. M., Malloy, M. J., Luke, M. M., Iakoubova, O. A., Pullinger, C. R., Cassano, J., Aouizerat, B. E., Fenwick, R. G., Reitz, R. E., Catanese, J. J., Leong, D. U., Zellner, C., Sninsky, J. J., Topol, E. J., Devlin, J. J., Kane, J. P. Identification of four gene variants associated with myocardial infarction. Am. J. Hum. Genet. 77: 596-605, 2005. [PubMed: 16175505] [Full Text: https://doi.org/10.1086/491674]


Contributors:
Marla J. F. O'Neill - updated : 12/14/2007

Creation Date:
Patricia A. Hartz : 12/14/2007

Edit History:
carol : 12/14/2007
carol : 12/14/2007



NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: June 5, 2024