Entry - *611700 - SV2-RELATED PROTEIN-LIKE; SVOPL - OMIM

 
 
* 611700

SV2-RELATED PROTEIN-LIKE; SVOPL


HGNC Approved Gene Symbol: SVOPL

Cytogenetic location: 7q34     Genomic coordinates (GRCh38): 7:138,594,285-138,701,362 (from NCBI)


TEXT

▼ Cloning and Expression

By searching a human database for sequences similar to the SLC22 family of anion transporters (see SLC22A1, 602607), Jacobsson et al. (2007) identified SVOPL. The deduced 491-amino acid protein has 12 putative transmembrane domains and shows sequence similarity with the synaptic vesicle protein SVOP (611699). Quantitative real-time PCR detected high expression of rat Svopl in coronal brain sections of the olfactory bulb and frontal cortex. Much lower expression was detected in other coronal sections, and little to no expression was detected in peripheral tissues.


▼ Gene Structure

Jacobsson et al. (2007) determined that the SVOPL gene contains 13 exons.


▼ Mapping

Jacobsson et al. (2007) stated that the SVOPL gene maps to chromosome 7q34; the mouse Svopl gene maps to chromosome 6qB1.


▼ REFERENCES

  1. Jacobsson, J. A., Haitina, T., Lindblom, J., Fredriksson, R. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. Genomics 90: 595-609, 2007. [PubMed: 17714910, related citations] [Full Text]


Creation Date:
Patricia A. Hartz : 12/21/2007
Edit History:
carol : 12/21/2007

* 611700

SV2-RELATED PROTEIN-LIKE; SVOPL


HGNC Approved Gene Symbol: SVOPL

Cytogenetic location: 7q34     Genomic coordinates (GRCh38): 7:138,594,285-138,701,362 (from NCBI)


TEXT

Cloning and Expression

By searching a human database for sequences similar to the SLC22 family of anion transporters (see SLC22A1, 602607), Jacobsson et al. (2007) identified SVOPL. The deduced 491-amino acid protein has 12 putative transmembrane domains and shows sequence similarity with the synaptic vesicle protein SVOP (611699). Quantitative real-time PCR detected high expression of rat Svopl in coronal brain sections of the olfactory bulb and frontal cortex. Much lower expression was detected in other coronal sections, and little to no expression was detected in peripheral tissues.


Gene Structure

Jacobsson et al. (2007) determined that the SVOPL gene contains 13 exons.


Mapping

Jacobsson et al. (2007) stated that the SVOPL gene maps to chromosome 7q34; the mouse Svopl gene maps to chromosome 6qB1.


REFERENCES

  1. Jacobsson, J. A., Haitina, T., Lindblom, J., Fredriksson, R. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. Genomics 90: 595-609, 2007. [PubMed: 17714910] [Full Text: https://doi.org/10.1016/j.ygeno.2007.03.017]


Creation Date:
Patricia A. Hartz : 12/21/2007

Edit History:
carol : 12/21/2007



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: June 13, 2024