Entry - *611997 - MITOCHONDRIAL RIBOSOMAL PROTEIN 63; MRP63 - OMIM

 
 
* 611997

MITOCHONDRIAL RIBOSOMAL PROTEIN 63; MRP63


HGNC Approved Gene Symbol: MRPL57

Cytogenetic location: 13q12.11     Genomic coordinates (GRCh38): 13:21,176,658-21,179,084 (from NCBI)


TEXT

▼ Description

Mitochondria have their own translation system for production of 13 proteins essential for oxidative phosphorylation. MRP63 is 1 of more than 70 protein components of mitochondrial ribosomes that are encoded by the nuclear genome (Kenmochi et al., 2001).


▼ Cloning and Expression

By searching databases using bovine Mrp63 as query, followed by PCR of human genomic DNA, Kenmochi et al. (2001) cloned MRP63.


▼ Gene Structure

Zhang and Gerstein (2003) determined that the MRP63 gene has no introns in its coding region.


▼ Mapping

Using radiation hybrid analysis and analysis of an integrated BAC-STS map, Kenmochi et al. (2001) mapped the MRP63 gene to chromosome 13p11.1-q11. By genomic sequence analysis, Zhang and Gerstein (2003) mapped the MRP63 gene to chromosome 13q12.11. They identified 10 MRP63 pseudogenes scattered throughout the genome.


▼ REFERENCES

  1. Kenmochi, N., Suzuki, T., Uechi, T., Magoori, M., Kuniba, M., Higa, S., Watanabe, K., Tanaka, T. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. Genomics 77: 65-70, 2001. [PubMed: 11543634, related citations] [Full Text]

  2. Zhang, Z., Gerstein, M. Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. Genomics 81: 468-480, 2003. [PubMed: 12706105, related citations] [Full Text]


Creation Date:
Patricia A. Hartz : 4/21/2008
Edit History:
mgross : 04/23/2008

* 611997

MITOCHONDRIAL RIBOSOMAL PROTEIN 63; MRP63


HGNC Approved Gene Symbol: MRPL57

Cytogenetic location: 13q12.11     Genomic coordinates (GRCh38): 13:21,176,658-21,179,084 (from NCBI)


TEXT

Description

Mitochondria have their own translation system for production of 13 proteins essential for oxidative phosphorylation. MRP63 is 1 of more than 70 protein components of mitochondrial ribosomes that are encoded by the nuclear genome (Kenmochi et al., 2001).


Cloning and Expression

By searching databases using bovine Mrp63 as query, followed by PCR of human genomic DNA, Kenmochi et al. (2001) cloned MRP63.


Gene Structure

Zhang and Gerstein (2003) determined that the MRP63 gene has no introns in its coding region.


Mapping

Using radiation hybrid analysis and analysis of an integrated BAC-STS map, Kenmochi et al. (2001) mapped the MRP63 gene to chromosome 13p11.1-q11. By genomic sequence analysis, Zhang and Gerstein (2003) mapped the MRP63 gene to chromosome 13q12.11. They identified 10 MRP63 pseudogenes scattered throughout the genome.


REFERENCES

  1. Kenmochi, N., Suzuki, T., Uechi, T., Magoori, M., Kuniba, M., Higa, S., Watanabe, K., Tanaka, T. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. Genomics 77: 65-70, 2001. [PubMed: 11543634] [Full Text: https://doi.org/10.1006/geno.2001.6622]

  2. Zhang, Z., Gerstein, M. Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. Genomics 81: 468-480, 2003. [PubMed: 12706105] [Full Text: https://doi.org/10.1016/s0888-7543(03)00004-1]


Creation Date:
Patricia A. Hartz : 4/21/2008

Edit History:
mgross : 04/23/2008



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 27, 2024