Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Antifertility activity in gerbils assessed as inhibition of spermatid production at 25 mg/kg, po (Rvb = 51.2 %)
Assay data:1 Tested
SummaryPubMed Citation
Cerebral protective activity in anesthetized cerebral ischemia-induced Mongolian gerbil hippocampus assessed as protective values on density of surviving neurons in CA1 subfields of hippocampus at 100 mg/kg, po pretreated for 30 mins followed by bilateral ligation-induced ischemia for 5 mins measured on day 1 post 3 days ischemia induction by hematoxylin and eosin staining based microscopic analysis relative to control
Assay data:23 Tested
Cerebral protective activity in cerebral ischemia-induced Mongolian gerbil assessed as passive avoidance test value at 100 mg/kg, po pretreated for 30 mins followed by bilateral ligation-induced ischemia for 5 mins measured on day 1 post 3 days ischemia induction relative to control
Cmax in Mongolian gerbils plasma
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Plasma concentration in gerbil at 30 mg/kg, po
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Plasma concentration in gerbil at 75 mg/kg, po
Plasma concentration in gerbil at 10 mg/kg, po
Antagonist activity at endothelin A receptor in Mongolian gerbil spiral modiolar artery assessed as inhibition of ET-1-induced vasoconstriction at 0.1 to 1 uM treated for 2 mins with ET-1 addition for first min of compound treatment followed by compound washout and again ET-1 addition by video microscopic analysis
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
Assay data:53 Active, 11 Activity ≤ 1 nM, 53 Activity ≤ 1 µM, 53 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of [3H]GR205171 from Mongolian gerbil brain NK1 receptor after 60 mins by scintillation counting analysis
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to gerbil NK1 receptor
Cmax in Mongolian gerbils plasma at 0.5 mg, ip
Binding affinity to gerbil NK3 receptor
Concentration in po dosed Gerbil plasma after 45 mins at Occ90
Neuroprotective activity against BCCO-induced transient cerebral ischemia in mongolian gerbil hippocampal CA1 region assessed as increase in Hsp70 activity at 20 mg/kg, ip administered 20 mins prior to BCCO treatment measured after 24 hrs by immunostaining analysis
Neuroprotective activity against BCCO-induced transient cerebral ischemia in mongolian gerbil hippocampal CA1 region assessed as increase in viable neurons at 100 mg/kg, ip administered immediately after BCCO treatment and measured after 7 days by hematoxylin and eosin staining-based light microscopic analysis relative to control
Neuroprotective activity against BCCO-induced transient cerebral ischemia in mongolian gerbil hippocampal CA1 region assessed as increase in viable neurons at 20 mg/kg, ip administered 20 mins prior to BCCO treatment and measured after 7 days by hematoxylin and eosin staining-based light microscopic analysis relative to control
Neuroprotective activity against BCCO-induced transient cerebral ischemia in mongolian gerbil hippocampal CA1 region assessed as increase in viable neurons at 100 mg/kg, ip administered immediately after BCCO treatment and measured after 7 days by hematoxylin and eosin staining-based light microscopic analysis
Ratio of drug level in brain against plasma in Mongolian gerbil
Assay data:3 Tested
Inhibition of GR73632-induced hind foot tapping in orally dosed mongolian gerbil measured over 5 mins
Summary
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on