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Competitive Radioligand Binding Assay from US Patent US11691947: "Isoindoline compositions and methods for treating neurodegenerative disease"
Assay data:81 Active, 3 Activity ≤ 1 nM, 79 Activity ≤ 1 µM, 93 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Enzyme Inhibition Assay from US Patent US9162991: "Cinnamoyl inhibitors of transglutaminase"
Assay data:3 Active, 53 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Competitive Radioligand Binding Assay 2 from US Patent US11214540: "Compositions for treating neurodegenerative diseases"
Assay data:88 Active, 14 Activity ≤ 1 nM, 87 Activity ≤ 1 µM, 88 Tested
radioligand binding assay from US Patent US11147820: "Methods for treating GI tract disorders"
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
AO Enzyme Assay from Article 10.1016/j.bioorg.2015.12.004: "Inhibition of guinea pig aldehyde oxidase activity by different flavonoid compounds: An in vitro study."
Assay data:2 Active, 11 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding Assay from Article 10.1007/s00044-005-0131-1: "Novel 2(3H)-benzothiazolones as highly potent and selective sigma-1 receptor ligands"
Assay data:17 Active, 3 Activity ≤ 1 nM, 18 Activity ≤ 1 µM, 18 Tested
Sigma 1 Assay from Article 10.1111/j.1747-0285.2011.01215.x: "Synthesis and in vitro Evaluation of Novel Indole-Based Sigma Receptors Ligands."
Assay data:9 Active, 6 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition Assay from US Patent USRE47351: "2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists"
Assay data:10 Active, 7 Activity ≤ 1 µM, 11 Tested
Radioligand Binding Assay from Article 10.1124/jpet.103.061754: "A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties."
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Radioligand Labeled Binding Assay from Article 10.1021/jm061048b: "Synthesis of Stable and Potent delta/mu Opioid Peptides: Analogues of H-Tyr-c[d-Cys-Gly-Phe-d-Cys]-OH by Ring-Closing Metathesis."
Assay data:6 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Binding Assay from US Patent US9617281: "Imidazo[2,1-b]thiazole derivatives, their preparation and use as medicaments"
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
Binding Assay from US Patent US9567338: "Pyrazolo[3,4-d]pyrimidine compounds, their preparation and use as sigma ligands"
Assay data:60 Active, 60 Activity ≤ 1 µM, 60 Tested
Metabolic stability in guinea pig hepatocyte assessed as intrinsic clearance measured per 10^6 cells
Assay data:1 Tested
SummaryPubMed Citation
Plasma protein binding in guinea pig
Cardiovascular toxicity in po dosed guinea pig assessed as NOAEL
Activation of SERCA1 activity in guinea pig skeletal muscle microsome from hind leg assessed as increase in SERCA1-Ca2+ affinity by measuring reversal of PLN (1-12)-induced shift in dissociation of calcium
Assay data:2 Tested
Activation of SERCA1 activity in guinea pig skeletal muscle microsome from hind leg assessed as increase in SERCA1-Ca2+ affinity by measuring Kd of calcium at 30 to 1000 nM preincubated for 5 mins followed by addition of 32-P-ATP measured after 15 mins in presence of PLN (1-12) relative to control
Activation of SERCA1 activity in guinea pig skeletal muscle microsome from hind leg assessed as increase in SERCA1-Ca2+ affinity by measuring Kd of calcium at 30 to 1000 nM preincubated for 5 mins followed by addition of 32-P-ATP measured after 15 mins in absence of PLN relative to control
Activation of SERCA2a activity in guinea pig heart sarcoplasmic reticulum microsomal fraction assessed as increase in SERCA2a-Ca2+ affinity by measuring Kd of calcium at 100 nM preincubated for 5 mins followed by addition of 32-P-ATP measured after 15 mins relative to control
Assay data:9 Tested
Activation of SERCA2a activity in guinea pig heart sarcoplasmic reticulum microsomal fraction assessed as increase in SERCA2a-Ca2+ affinity by measuring Kd of calcium at 1 nM preincubated for 5 mins followed by addition of 32-P-ATP measured after 15 mins
Assay data:3 Tested
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