txid10359[Organism:exp] - PubChem BioAssay - NCBI

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Select item 19550501.

Inhibition of HCMV DNA polymerase incubated for 10 mins in presence of dNTP by fluorescence based assay

Source:: ChEMBL

Assay data:11 Active, 7 Activity ≤ 1 µM, 11 Tested

AID:: 1955050

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 19550452.

Antiviral activity against HCMV US3-6-EGFP-HCMV-AD169 infected in MRC5 cells assessed as inhibition of viral cytopathic effect incubated for 4 days by fluorescence based HTS assay

Source:: ChEMBL

Assay data:14 Active, 9 Activity ≤ 1 µM, 16 Tested

AID:: 1955045

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 19516913.

Antiviral activity against Human betaherpesvirus 5

Source:: ChEMBL

Assay data:2 Active, 2 Tested

AID:: 1951691

Summary Compounds, Active PubMed Citation

Select item 19516834.

Antiviral activity against Human betaherpesvirus 5 AD 169 infected in HFF cells

Source:: ChEMBL

Assay data:1 Active, 2 Tested

AID:: 1951683

Summary Compounds, Active PubMed Citation

Select item 19469485.

Antiviral activity against HCMV Davis infected in HELF cells assessed as reduction in viral replication

Source:: ChEMBL

Assay data:2 Active, 1 Activity ≤ 1 µM, 7 Tested

AID:: 1946948

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 19469476.

Antiviral activity against HCMV AD-169 infected in HELF cells assessed as reduction in viral replication

Source:: ChEMBL

Assay data:2 Active, 7 Tested

AID:: 1946947

Summary Compounds, Active PubMed Citation

Select item 19156667.

Antiviral activity against ganciclovir sensitive HCMV infected in human HELF cells assessed as viral growth inhibition incubated for 8 days

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1915666

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 19156658.

Antiviral activity against ganciclovir resistant HCMV infected in human HELF cells assessed as viral growth inhibition incubated for 8 days

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1915665

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 18762299.

Antiviral activity against HCMV assessed as inhibition of DNA synthesis at 10 uM relative to control

Source:: ChEMBL

Assay data:1 Tested

AID:: 1876229

Summary PubMed Citation

Select item 187617510.

Antiviral activity against HCMV

Source:: ChEMBL

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1876175

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 187613111.

Antiviral activity against HCMV at 1 uM relative to control

Source:: ChEMBL

Assay data:1 Tested

AID:: 1876131

Summary PubMed Citation

Select item 187601212.

Antiviral activity against HCMV Merlin (RCMV 1111) infected in HFF cells incubated for 96 hrs

Source:: ChEMBL

Assay data:1 Active, 1 Tested

AID:: 1876012

Summary Compounds, Active PubMed Citation

Select item 187601113.

Antiviral activity against HCMV AD169 infected in HFF cells incubated for 96 hrs

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1876011

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 186961614.

Antiviral activity against HCMV AD-169 infected in HFF cells assessed as reduction in viral replication measured after 14 days

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 7 Tested

AID:: 1869616

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 186961115.

Antiviral activity against HCMV Davis infected in HEL cells assessed as reduction in virus plaque formation

Source:: ChEMBL

Assay data:3 Active, 1 Activity ≤ 1 µM, 7 Tested

AID:: 1869611

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 186961016.

Antiviral activity against HCMV AD-169 infected in HEL cells assessed as reduction in virus plaque formation

Source:: ChEMBL

Assay data:3 Active, 1 Activity ≤ 1 µM, 7 Tested

AID:: 1869610

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 185496517.

Antiviral activity against Human cytomegalovirus Davis infected in HEL cells assessed as reduction in virus-induced cytopathic effect by microscopic analysis

Source:: ChEMBL

Assay data:2 Active, 2 Activity ≤ 1 µM, 6 Tested

AID:: 1854965

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 185496418.

Antiviral activity against Human cytomegalovirus AD-169 infected in HEL cells assessed as reduction in virus-induced cytopathic effect by microscopic analysis

Source:: ChEMBL

Assay data:2 Active, 1 Activity ≤ 1 µM, 6 Tested

AID:: 1854964

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 181121119.

Potency index, ratio of Mannan IC50 to test compound IC50 for antiviral activity against HCMV infected in U-937 cells expressed in DC-SIGN using flow cytometry

Source:: ChEMBL

Assay data:4 Tested

AID:: 1811211

Summary PubMed Citation

Select item 181121020.

Antiviral activity against HCMV infected in U-937 cells expressed in DC-SIGN using flow cytometry

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 5 Tested

AID:: 1811210

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

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Target

Proteins (32)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (612)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (9)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (312)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (535)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (1)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

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Literature Extraction (1,028)
BioAssays extracted from the literature
Other (1)
BioAssays deposited by other experimentalists

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txid10359[Organism:exp] (1029)
PubChem BioAssay
Fam177a1 family with sequence similarity 177, member A1 [Rattus norvegicus]
Fam177a1 family with sequence similarity 177, member A1 [Rattus norvegicus]
Gene ID:100359558

Gene

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