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HCV NS5B Pol assay ([32P]-UTP) from US Patent US11857560: "Pharmaceutical compositions comprising substituted nucleotides and nucleosides for treating viral infections"
Assay data:9 Active, 3 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
HCV NS5B Pol assay ([32P]-CTP]) from US Patent US11857560: "Pharmaceutical compositions comprising substituted nucleotides and nucleosides for treating viral infections"
Assay data:7 Active, 1 Activity ≤ 1 µM, 11 Tested
RNA-Dependent RNA HCV NS5B (polymerase) Assay and IC50 Determination from US Patent US10947210: "Inhibitors of Hepatitis C virus polymerase"
Assay data:67 Active, 135 Activity ≤ 1 µM, 135 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Depositor
Reporter Assay from US Patent US9428469: "Antiviral compounds"
Assay data:17 Active, 6 Activity ≤ 1 µM, 29 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition Assay from US Patent US9365582: "Macrocyclic inhibitors of hepatitis C virus"
Assay data:12 Active, 7 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 12 Tested
Antiviral Activity from US Patent US10226449: "Heterocyclic modulators of lipid synthesis and combinations thereof"
Assay data:243 Active, 5 Activity ≤ 1 nM, 225 Activity ≤ 1 µM, 254 Tested
HCV Replicon Assay Luciferase from US Patent US9669095: "Cyclosporin analogues for preventing or treating hepatitis C infection"
Assay data:12 Active, 13 Activity ≤ 1 µM, 13 Tested
Pseudotyped HCV particle (HCVpp) reporter assay from US Patent US9693997: "Antiviral compounds"
Assay data:290 Active, 1 Activity ≤ 1 nM, 272 Activity ≤ 1 µM, 293 Tested
Rhinovirus Polymerase (HRV1bpol) and HCV Polymerase (HCVpol) Assays from US Patent US11149049: "Substituted nucleosides, nucleotides and analogs thereof"
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Measuring Compound Inhibitory Potency from US Patent US11053243: "Inhibitors of hepatitis C virus replication"
Assay data:50 Active, 39 Activity ≤ 1 nM, 50 Activity ≤ 1 µM, 50 Tested
HCV Replicon Assay and EC50 Determination from US Patent US10947210: "Inhibitors of Hepatitis C virus polymerase"
Assay data:24 Active, 24 Activity ≤ 1 µM, 24 Tested
Inhibition Assay from US Patent US10793591: "Substituted nucleosides, nucleotides and analogs thereof"
Assay data:15 Active, 14 Activity ≤ 1 µM, 15 Tested
HCV Polymerase Enzyme Assay from US Patent US10513534: "2′-chloro nucleoside analogs for HCV infection"
Assay data:10 Active, 2 Activity ≤ 1 µM, 11 Tested
Inhibition Assay from US Patent US9457039: "2′-disubstituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases"
Assay data:3 Active, 1 Activity ≤ 1 µM, 4 Tested
Cell-Based HCV Replicon Assay from US Patent US9457039: "2′-disubstituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases"
Assay data:1 Active, 15 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
NS5B RNA Polymerase Assay from US Patent US9447132: "Highly active nucleoside derivative for the treatment of HCV"
Assay data:2 Active, 2 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Transient Transfection Assay from US Patent US9433609: "Benzimidazole-imidazole derivatives"
Assay data:20 Active, 18 Activity ≤ 1 nM, 20 Activity ≤ 1 µM, 20 Tested
Stable Transfection Assay from US Patent US9433609: "Benzimidazole-imidazole derivatives"
Immumoenzymatic Assay from US Patent US9428491: "Substituted azoles, antiviral active component, pharmaceutical composition, method for preparation and use thereof"
Assay data:10 Active, 10 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 10 Tested
Surface Plasmon Resonance (SPR)-Based Assay from US Patent US9427440: "Macrocyclic indole derivatives useful as hepatitis C virus inhibitors"
Assay data:9 Active, 9 Activity ≤ 1 µM, 9 Tested
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