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Antiviral activity against HCV-1 infected in human LucUbiNeo-ET cells assessed as reduction in viral replication incubated for 2 days by luminometry
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antiviral activity against HCV-1 infected in human Huh-7 cells assessed as reduction in viral replication
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Antiviral activity against HCV-1 infected in hepatoma cells (unknown origin) assessed as reduction in viral replication
Assay data:1 Tested
SummaryPubMed Citation
Inhibition of deltaC55 truncated Hepatitis C virus NS5B expressed in Escherichia coli using poly(rA)/oligo(rU) as template/primer incubated for 20 mins in presence of 3H-UTP by radioactivity based assay
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antiviral activity against HCV infected in human Huh-5-2 cells assessed as reduction in viral replication measured by Luciferase reporter gene assay
Assay data:3 Tested
Antiviral activity against HCV infected in human Huh7.5 cells assessed as reduction in viral RNA expression at 10 uM pretreated for 1 hr followed by viral infection and measured after 48 hrs by RT-qPCR analysis
Assay data:2 Tested
Inhibition of C-terminal his6-tagged HCV NS5/RNA-dependent RNA polymerase expressed in Escherichia coli at 100 uM incubated for 2 hrs by Microbeta counter analysis
Inhibition of HCV replication
Inhibition of HCV replicon cells
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Antiviral activity against HCV JFH-1 infected in Huh7.5.1 cells assessed as decrease in intracellular and extracellular HCV RNA level measured after 3 days by RT-qPCR assay
Disruption of hepatitis C virus-internal ribosome entry site (IRES) RNA base stacking interaction
Inhibition of HCV replication in human Huh7.5 cells cultured with SGR-Neo-RLuc-JFH1-2A replicon celIs measured after 72 hrs by luciferase assay
Antiviral activity against HCV infected in Huh-7.5.1 cells assessed as inhibition of HCV production measured after 24 hrs by titration assay
Inhibition of hepatitis C virus p7 ion channel
Antiviral activity against HCV GT-3a (S52) assessed as inhibition of viral replication measured by renilla luciferase assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Antiviral activity against HCV assessed as inhibition of viral fusion and replication at attachment stage
Antiviral activity against HCV pseudo-particle containing JFH1 glycoprotein E1/E2 heterodimers infected in human Huh7.5 cells assessed as inhibition of viral entry
Antiviral activity against HCV JFH-1 infected in Huh7.5 cells and measured after 72 hrs by Acridine orange staining method
Antiviral activity against HCV GT-1a expressing NS5B S365A mutant variant
Antiviral activity against HCV GT-1a expressing NS5B C316Y mutant variant
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