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Inhibition of [125I]alpha-bungarotoxin binding to nicotinic acetylcholine receptor alpha1 beta gamma delta of electroplax
Assay data:5 Active, 3 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Acetylcholinesterase Assay from Article 10.1016/j.bioorg.2016.07.005: "Synthesis and in vitro acetylcholinesterase and butyrylcholinesterase inhibitory potential of hydrazide based Schiff bases."
Assay data:4 Active, 1 Activity ≤ 1 µM, 22 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Enzyme Inhibition Assay from Article 10.1080/14756360802208053: "Synthesis and biological evaluation of new donepezil-like Thiaindanones as AChE inhibitors."
Assay data:7 Active, 5 Activity ≤ 1 µM, 11 Tested
Enzyme Inhibition Assay from Article 10.1080/14756360600889708: "New natural cholinesterase inhibiting and calcium channel blocking quinoline alkaloids."
Assay data:2 Active, 2 Activity ≤ 1 µM, 5 Tested
Enzyme Inhibition Assay from Article 10.1080/14756360400015231: "Synthesis and inhibitory potential towards acetylcholinesterase, butyrylcholinesterase and lipoxygenase of some variably substituted chalcones."
Assay data:12 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Enzyme Assay from Article 10.1002/1439-7633(20010601)2: "Dynamic deconvolution of a pre-equilibrated dynamic combinatorial library of acetylcholinesterase inhibitors."
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
In Vitro AChE Inhibition Assay from Article 10.1021/jm070536w: "New potent acetylcholinesterase inhibitors in the tetracyclic triterpene series."
Assay data:30 Active, 24 Activity ≤ 1 µM, 31 Tested
Cholinesterase Inhibition Assay from Article 10.1021/jm060742o: "Novel heterobivalent tacrine derivatives as cholinesterase inhibitors with notable selectivity toward butyrylcholinesterase."
Assay data:16 Active, 6 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 16 Tested
Cholinesterase Inhibition Assay from Article 10.1021/jm060293s: "Structural determinants of Torpedo californica acetylcholinesterase inhibition by the novel and orally active carbamate based anti-alzheimer drug ganstigmine (CHF-2819)."
Assay data:10 Active, 12 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Enzyme Inhibition Assay from Article 10.1021/bi020151+: "X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangement."
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Enzyme Inhibition Assay from Article 10.1021/bi020016x: "Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug rivastigmine."
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Enzyme Inhibition Assay from Article 10.1021/jm010826r: "A structure-based design approach to the development of novel, reversible AChE inhibitors."
Assay data:15 Active, 11 Activity ≤ 1 µM, 20 Tested
Enzyme Inhibition Assay from Article 10.1021/ja021111w: "Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity."
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Enzyme Inhibition Assay from Article 10.1016/s0968-0896(98)00133-3: "Potent acetylcholinesterase inhibitors: design, synthesis, and structure-activity relationships of bis-interacting ligands in the galanthamine series."
Assay data:30 Active, 18 Activity ≤ 1 µM, 32 Tested
Enzyme Inhibition Assay from Article 10.1021/ja0466154: "The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design."
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of Pacific electric ray AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 2 mins by Ellman's method
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Pacific electric ray AChE using acetylthiocholine iodide as substrate by Ellman's method
Agonist activity at Torpedo alpha1beta1deltagamma nACHR
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Pseudo-irreversible inhibition of Torpedo californica AChE using acetylthiocholine as substrate by cornish bowden plot analysis
Noncompetitive inhibition of Torpedo californica AChE using ATCh as substrate assessed as dissociation rate constant preincubated for 90 mins followed by substrate addition by potentiometric titration method
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