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bBiDomain assay from Article 10.1021/acs.biochem.6b00786: "Targeting Bacterial Nitric Oxide Synthase with Aminoquinoline-Based Inhibitors."
Assay data:2 Tested
SummaryPubMed Citation
Activity-based Protein Profiling (ABPP) from Article 10.1021/acschembio.5b00514: "Inhibitor Fingerprinting of Rhomboid Proteases by Activity-Based Protein Profiling Reveals Inhibitor Selectivity and Rhomboid Autoprocessing."
Assay data:3 Active, 1 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Imidazole Spin Shift Assay from Article 10.1021/acs.biochem.5b00431: "Inhibitor Bound Crystal Structures of Bacterial Nitric Oxide Synthase."
Assay data:6 Active, 1 Activity ≤ 1 µM, 24 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
DNA Gyrase Activity Assay from Article 10.1128/AAC.01311-05: "Antibacterial activity and mechanism of action of a novel anilinouracil-fluoroquinolone hybrid compound."
Assay data:2 Active, 5 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Depositor
DNA Topoisomerase IV Assay from Article 10.1128/AAC.01311-05: "Antibacterial activity and mechanism of action of a novel anilinouracil-fluoroquinolone hybrid compound."
DNA Polymerase Activity Assay from Article 10.1128/AAC.01311-05: "Antibacterial activity and mechanism of action of a novel anilinouracil-fluoroquinolone hybrid compound."
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Antibacterial activity against Bacillus subtilis assessed as bacterial growth inhibition by CLSI protocol based broth microdilution assay
Assay data:5 Tested
Inhibition of Bacillus subtilis RuvA/RuvB protein complex helicase activity expressed in Escherichia coli BL21(DE3) assessed as inhibition of HJ branch migration at 50 uM preincubated for 15 mins followed by substrate addition and measured after 1 hr using 5'-FAM labelled 5'-CACTGTGATGCACGATGATTGACGACAGTAGTCAGTGCTGCAGTGGTCAGGTGTC-3' HJ-a duplex DNA as substrate in presence of ATP by PAGE analysis
Assay data:1 Tested
Inhibition of Bacillus subtilis RuvA/RuvB protein complex helicase activity expressed in Escherichia coli BL21(DE3) assessed as inhibition of HJ branch migration preincubated for 15 mins followed by substrate addition and measured after 1 hr using 5'-FAM labelled 5'-CACTGTGATGCACGATGATTGACGACAGTAGTCAGTGCTGCAGTGGTCAGGTGTC-3' HJ-a duplex DNA as substrate in presence of ATP by PAGE analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Antibacterial activity against Bacillus subtilis NCIM 2079 assessed as reduction in bacterial growth incubated for 8 hrs by absorbance based assay
Assay data:9 Active, 9 Activity ≤ 1 µM, 9 Tested
Antibacterial activity against Bacillus subtilis NCIM 2079 assessed as bacterial growth inhibition incubated for 8 hrs by absorbance based assay
Assay data:9 Tested
Displacement of BODIPY-TR-cadaverine from Bacillus subtilis Lipoteichoic acid at 8 times MIC measured for 30 mins by fluorescence based microplate reader assay relative to control
Displacement of BODIPY-TR-cadaverine from Bacillus subtilis Lipoteichoic acid at 4 times MIC measured for 30 mins by fluorescence based microplate reader assay relative to control
Displacement of BODIPY-TR-cadaverine from Bacillus subtilis Lipoteichoic acid at 2 times MIC measured for 30 mins by fluorescence based microplate reader assay relative to control
Displacement of BODIPY-TR-cadaverine from Bacillus subtilis Lipoteichoic acid at 1 times MIC measured for 30 mins by fluorescence based microplate reader assay relative to control
Induction of drug resistance against Bacillus subtilis CMCC (B) 63501 measured after 16 passages
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Induction of morphological changes in Bacillus subtilis CMCC (B) 63501 assessed as elongation of bacterial cell at 0.5 times MIC for 4 hrs (Rvb = 3 to 5 um) by microscopic analysis
Assay data:4 Tested
Bactericidal activity against Bacillus subtilis CMCC (B) 63501 assessed as inhibition of bacterial growth incubated for 24 hrs by resazurin dye based microtiter plate assay
Antibacterial activity against Bacillus subtilis CMCC (B) 63501 assessed as inhibition of bacterial growth incubated for 20 to 24 hrs by broth micro dilution method
Assay data:24 Tested
Ratio of MBC for bactericidal activity against Bacillus subtilis CMCC (B) 63501 to MIC for antibacterial activity against Bacillus subtilis CMCC (B) 63501
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