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PDF Inhibition Assay from Article 10.1110/ps.0229303: "Structural variation and inhibitor binding in polypeptide deformylase from four different bacterial species."
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of CrtN in methicillin-resistant Staphylococcus aureus Mu50 assessed as reduction in staphyloxanthin levels after 48 hrs by spectrophotometric method-based pigment inhibition assay
Assay data:3 Active, 3 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of methicillin-resistant Staphylococcus aureus Mu50 TRAP assessed as potentiation of vancomycin-induced antibiofilm activity cotreated with vancomycin for 24 hrs
Assay data:6 Active, 28 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of methicillin-resistant Staphylococcus aureus Mu50 TRAP assessed as potentiation of vancomycin-induced antibiofilm activity treated for 4 hrs prior to vancomycin addition measured after 20 hrs
Assay data:8 Active, 2 Activity ≤ 1 µM, 28 Tested
Inhibition of CrtN in Staphylococcus aureus Mu50 assessed as reduction in staphyloxanthin levels after 48 hrs by spectrophotometric analysis
Assay data:5 Active, 3 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of quorum sensing system in methicillin-resistant Staphylococcus aureus Mu50 assessed as potentiation of vancomycin-mediated reduction in CFU/biofilm after 24 hrs
Assay data:2 Active, 9 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of quorum sensing system in methicillin-resistant Staphylococcus aureus Mu50 assessed as potentiation of vancomycin-mediated reduction in CFU/biofilm preincubated for 20 hrs followed by vancomycin addition measured after 24 hrs
Assay data:3 Active, 1 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of CrtN in vancomycin-intermediate Staphylococcus aureus Mu50 assessed as reduction in staphyloxanthin levels after 48 hrs by spectrophotometric method-based pigment inhibition assay
Assay data:4 Active, 2 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus Mu50 ATCC 700699 measured after overnight incubation by microdilution broth method
Assay data:10 Tested
SummaryPubMed Citation
Inhibition of diapophytoene desaturase in methicillin-resistant Staphylococcus aureus Mu 50 assessed as reduction in staphyloxanthin pigment formation after 48 hrs by spectrophotometry
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of Staphylococcus aureus peptide deformylase
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibitory concentration against Staphylococcus aureus beta-Ketoacyl-acyl carrier protein synthase III
Assay data:2 Active, 4 Tested
Inhibition of Peptidyl deformylase (PDF)
Assay data:7 Active, 5 Activity ≤ 1 µM, 14 Tested
Inhibitory activity towards Ni-peptide deformylase of Staphylococcus aureus
Assay data:32 Active, 32 Activity ≤ 1 µM, 36 Tested
Inhibition of methicillin-resistant Staphylococcus aureus Mu50 TRAP assessed as reduction in vancomycin MIC at 100 uM
Assay data:2 Tested
Inhibition of CrtN in Staphylococcus aureus Mu50 assessed as H2O2-induced bacterial death by measuring reduction in bacterial survival at 1 uM preincubated for 24 hrs followed by H2O2 addition measured after 30 mins by serial dilution method
Assay data:1 Active, 1 Tested
Antimicrobial activity against hospital-acquired pbp4-deficient Staphylococcus aureus Mu50 serotype USA100 by microdilution method
Assay data:3 Tested
Antimicrobial activity against wild type hospital-acquired methicillin-resistant vancomycin-intermediate Staphylococcus aureus Mu50 serotype USA100 by microdilution method
Antibacterial activity against Staphylococcus aureus Mu50 ATCC 700699 by broth microdilution method
Assay data:11 Tested
Ratio of MBC to MIC for vancomycin-intermediate resistant Staphylococcus aureus Mu50 ATCC 700699
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