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Antimycobacterial activity against Mycobacterium tuberculosis H37Rv assessed as reduction in bacterial growth by MABA assay
Assay data:1 Tested
SummaryPubMed Citation
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv assessed as reduction in bacterial cell growth
Antibacterial activity against Mycobacterium bovis BCG harboring pTIC6-fbpA overexpressing Ag85A by end point resazurin assay
Antibacterial activity against Mycobacterium bovis BCG harboring pTIC6-fbpC overexpressing Ag85C assessed as fold increase in MIC by end point resazurin assay relative to empty vector control
Assay data:3 Tested
Antibacterial activity against Mycobacterium bovis BCG harboring pTIC6-fbpB overexpressing Ag85B assessed as fold increase in MIC by end point resazurin assay relative to empty vector control
Inhibition of late-stage mycolic acid biosynthesis in Mycobacterium bovis BCG at 5 times MIC incubated for 6 hrs by TLC based autoradiography analysis
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of mycolic acid biosynthesis in Mycobacterium bovis BCG assessed as decrease in keto mycolic acid transfer onto cell wall arabinogalactan at 0.5 times MIC incubated for 12 hrs in presence of [14C]acetate by TLC based autoradiography analysis
Assay data:1 Active, 1 Tested
Inhibition of mycolic acid biosynthesis in Mycobacterium bovis BCG assessed as decrease in alpha mycolic acid transfer onto cell wall arabinogalactan at 0.5 times MIC incubated for 12 hrs in presence of [14C]acetate by TLC based autoradiography analysis
Inhibition of cell wall biosynthesis in Mycobacterium bovis BCG assessed as formation of cytoplasmic membrane phospholipids at 0.5 times MIC incubated for 12 hrs in presence of [14C]acetate by TLC based autoradiography analysis
Inhibition of cell wall biosynthesis in Mycobacterium bovis BCG assessed as reduction in trehalose dimycolate accumulation at 0.5 times MIC incubated for 12 hrs in presence of [14C]acetate by TLC based autoradiography analysis
Inhibition of cell wall biosynthesis in Mycobacterium bovis BCG assessed as reduction in trehalose monomycolate accumulation at 0.5 times MIC incubated for 12 hrs in presence of [14C]acetate by TLC based autoradiography analysis
Upregulation of mmpS5 gene expression in Mycobacterium bovis BCG at 1 times MIC incubated for 8 hrs by RNA-sequencing analysis
Upregulation of mmpL5 gene expression in Mycobacterium bovis BCG at 1 times MIC incubated for 8 hrs by RNA-sequencing analysis
Effect on narG-J gene expression in Mycobacterium bovis BCG at 1 times MIC incubated for 8 hrs by RNA-sequencing analysis
Effect on cydA-D gene expression in Mycobacterium bovis BCG at 1 times MIC incubated for 8 hrs by RNA-sequencing analysis
Effect on ctaC-E gene expression in Mycobacterium bovis BCG at 1 times MIC incubated for 8 hrs by RNA-sequencing analysis
Effect on qcrA-C gene expression in Mycobacterium bovis BCG at 1 times MIC incubated for 8 hrs by RNA-sequencing analysis
Effect on nuoA-N gene expression in Mycobacterium bovis BCG at 1 times MIC incubated for 8 hrs by RNA-sequencing analysis
Upregulation of mbtD gene expression in Mycobacterium bovis BCG at 1 times MIC incubated for 8 hrs by RNA-sequencing analysis
Upregulation of mbtC gene expression in Mycobacterium bovis BCG at 1 times MIC incubated for 8 hrs by RNA-sequencing analysis
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