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Inhibition of Aquifex aeolicus LpxC transformed in Escherichia coli BL21(DE3) pLysS cells
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
In Silico Screening from Article 10.1002/cbic.201700052: "Spectroscopic and Computational Investigations of Ligand Binding to IspH: Discovery of Non-diphosphate Inhibitors."
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
OctetRed from Article : "LPXC in CSAR_FULL_RELEASE_3JULY2012"
Assay data:13 Active, 3 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
ITC from Article : "LPXC in CSAR_FULL_RELEASE_3JULY2012"
Assay data:9 Active, 4 Activity ≤ 1 µM, 10 Tested
Thermofluor from Article : "LPXC in CSAR_FULL_RELEASE_3JULY2012"
Assay data:13 Active, 8 Activity ≤ 1 µM, 32 Tested
Fluorescent Coupled Assay from Article 10.1016/j.chembiol.2007.12.013: "Probing FtsZ and tubulin with C8-substituted GTP analogs reveals differences in their nucleotide binding sites."
Assay data:9 Tested
SummaryPubMed CitationRelated BioAssays by Depositor
Fluorescent Competition Assay from Article 10.1016/j.chembiol.2007.12.013: "Probing FtsZ and tubulin with C8-substituted GTP analogs reveals differences in their nucleotide binding sites."
Assay data:8 Active, 8 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
Ligand Affinity Measurements from Article 10.1016/j.bmc.2007.01.044: "Amphipathic benzoic acid derivatives: synthesis and binding in the hydrophobic tunnel of the zinc deacetylase LpxC."
Assay data:9 Active, 1 Activity ≤ 1 µM, 12 Tested
Inhibition of MraY in Aquifex aeolicus
Assay data:19 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Aquifex aeolicus MraY expressed in Escherichia coli C41(DE3) using Park's nucleotide as substrate pretreated for 30 mins followed by substrate addition measured up to 2 mins by fluorescence assay
Assay data:3 Active, 3 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 4 Tested
Inhibition of Aquifex aeolicus IspH expressed in Escherichia coli BL21 (DE3) using HMBPP substrate
Assay data:4 Active, 1 Activity ≤ 1 µM, 21 Tested
Binding affinity to Aquifex aeolicus LpxC by isothermal titration calorimetry
Assay data:7 Active, 11 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Aquifex aeolicus MraY using UDP-MurNAc-pentapeptide as substrate measured after 5 mins by UMP-Glo glycosyltransferase assay
Assay data:3 Tested
Inhibition of Aquifex aeolicus LpxC
Assay data:1 Active, 1 Tested
Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB
Assay data:3916 Active, 206 Activity ≤ 1 nM, 1830 Activity ≤ 1 µM, 3916 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB
Assay data:4302 Active, 250 Activity ≤ 1 nM, 2931 Activity ≤ 1 µM, 4302 Tested
Experimentally measured binding affinity data derived from PDB
Assay data:3073 Active, 3073 Tested
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