Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Inhibition of HPV-18 DNA amplification in C-33-A cells incubated for 48 hrs by luciferase reporter gene assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antiviral activity against HPV18 infected in human HEK293T cells assessed as viral growth inhibition incubated for 72 hrs by by green fluorescent protein based method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to HPV 18 CTTTGGCGCATATAA GGCGC LCR DNA (7585 to 7594 nucleotides) after 4 hrs by DNase I footprinting assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Binding affinity to HPV 18 ACATA TTTTGAACAA TTGGC LCR DNA (7559 to 7568 nucleotides) after 4 hrs by DNase I footprinting assay
Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Binding affinity to HPV 18 CCTGG TATTAGTCAT TTTCC LCR DNA (7606 to 7615 nucleotides) after 4 hrs by DNase I footprinting assay
Antiviral activity against HPV 18 infected in mouse 3T3 cells assessed as decrease in viral DNA after 48 hrs by qRT-PCR analysis
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Antiviral activity against HPV-18 infected in human HeLa cells assessed as inhibition of viral replication after 7 days
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Antiviral activity against HPV-18 infected in human HeLa cells assessed as inhibition of viral replication after 3 days
Inhibition of viral protein E7 in HPV18 infected in human HeLa cells assessed as reduction in DNMT1 protein at S780 residue after 24 hrs by Western blot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of viral protein E7 in HPV18 infected in human HeLa cells assessed as reduction in E2F-1 protein at S780 residue after 24 hrs by Western blot analysis
Inhibition of viral protein E7 in HPV18 infected in human HeLa cells assessed as reduction in phosphorylation of Rb at S780 residue after 24 hrs by Western blot analysis
Inhibition of viral protein E7 in HPV18 infected in human HeLa cells assessed as reduction in phosphorylation of Rb at S608 residue after 24 hrs by Western blot analysis
Down regulation of viral protein E7 in HPV18 infected in human C4-1 cells after 24 hrs by Western blot analysis
SummaryPubMed Citation
Down regulation of viral protein E6 in HPV18 infected in human C4-1 cells after 24 hrs by Western blot analysis
Down regulation of viral protein E7 in HPV18 infected in human HeLa cells after 24 hrs by Western blot analysis
Down regulation of viral protein E6 in HPV18 infected in human HeLa cells after 24 hrs by Western blot analysis
Inhibition of Human papillomavirus type18 derived E6 in human HeLa cells assessed as increase in p21 protein expression at 2 to 4 uM after 48 hrs by Western blot analysis
Inhibition of Human papillomavirus type18 derived E6 in human HeLa cells assessed as increase in p53 protein expression at 2 to 4 uM after 48 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to HPV 18 CCT GG TATTAGTCATTTTCCTG TCCA G GT LCR DNA (7606 to 7615 nucleotide) at 50 to 200 nM after 4 hrs by DNase I footprinting assay
Binding affinity to HPV 18 CCT GG TATTAGTCATTTTCCTG TCCA G GT LCR DNA (7606 to 7615 nucleotide) at 50 nM after 4 hrs by DNase I footprinting assay
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on