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P. falciparum growth and inhibition assays from US Patent US11903936: "Anti-malarial agents"
Assay data:12 Active, 12 Activity ≤ 1 µM, 12 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
DHODH Kinetic Analysis from US Patent US11903936: "Anti-malarial agents"
Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested
Inhibition of Plasmodium falciparum CDPK1
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of plasmodium falciparum phosphoethanolamine N-methyltransferase expressed in Escherichia coli using phosphoethanolamine as substrate and [methyl-14C] SAM by radiochemical assay
Assay data:1 Tested
SummaryPubMed Citation
Inhibition of plasmodium falciparum phosphoethanolamine N-methyltransferase expressed in Escherichia coli assessed as remaining enzyme activity at 100 uM using phosphoethanolamine as substrate and [methyl-14C] SAM by radiochemical assay
Assay data:4 Tested
Inhibition of Plasmodium falciparum phosphoethanolamine methyltransferase using phospethanolamine as substrate by radiochemical assay in presence of S-adenosylmethionine
Assay data:3 Tested
Enzyme Inhibition Assay from US Patent US9353089: "Compositions and methods for the treatment of malaria"
Assay data:80 Active, 76 Activity ≤ 1 µM, 82 Tested
Inhibiton Assay from US Patent US9238653: "Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase"
Assay data:53 Active, 44 Activity ≤ 1 µM, 53 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
TBD from US Patent US11365202: "Antimalarial compounds, process for preparation and their use for drug resistant malaria"
Assay data:6 Active, 10 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
DHODH Biochemical Assay from Article 10.1074/jbc.M114.558353: "In vitro resistance selections for Plasmodium falciparum dihydroorotate dehydrogenase inhibitors give mutants with multiple point mutations in the drug-binding site and altered growth."
Assay data:4 Active, 2 Activity ≤ 1 µM, 5 Tested
Enzyme Inhibition Assay from Article 10.1016/j.bmc.2008.08.012: "Achiral oligoamines as versatile tool for the development of aspartic protease inhibitors."
Assay data:7 Active, 1 Activity ≤ 1 µM, 11 Tested
DHODH Inhibition Assay from Article 10.1021/jm800963t: "Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases."
Assay data:17 Active, 15 Activity ≤ 1 µM, 17 Tested
DHODH Inhibition Assay from Article 10.1021/jm801343r: "Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice."
Assay data:25 Active, 9 Activity ≤ 1 µM, 43 Tested
DHODH Inhibition Assay from Article 10.1021/jm8001026: "Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum."
Assay data:10 Active, 6 Activity ≤ 1 µM, 14 Tested
DHODH Inhibition Assay from Article 10.1016/j.bmcl.2005.09.045: "The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase."
Assay data:4 Active, 1 Activity ≤ 1 µM, 6 Tested
DHODH Inhibition Assay from Article 10.1021/jm060687j: "Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase."
Assay data:8 Active, 5 Activity ≤ 1 µM, 13 Tested
Inhibition of Plasmodium falciparum 3D7 Prolyl-tRNA synthetase
Inhibition of Plasmodium falciparum 3D7 HA-glms-tagged PMIX at 10 nM using DABCYL-HSFIQEGKEE-EDANS as substrate measured after 2 hrs by FRET assay relative to control
Inhibition of Plasmodium falciparum 3D7 HA-glms-tagged PMX at 10 nM using DABCYL-HSFIQEGKEE-EDANS as substrate measured after 2 hrs by FRET assay relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Plasmodium falciparum 3D7 HA-glms-tagged PMIX using DABCYL-HSFIQEGKEE-EDANS as substrate measured after 2 hrs by FRET assay
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
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